Publication Name	World Journal of Gastroenterology
Manuscript ID	32366
Country	China

Received	2017-01-05 10:01
Peer-Review Started	2017-01-06 17:35
To Make the First Decision	2017-03-16 11:33
Return for Revision	2017-03-17 15:01
Revised	2017-03-30 11:07
Second Decision	2017-07-21 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-07-24 02:26
Articles in Press	2017-07-24 02:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-07-31 04:35
Typeset the Manuscript	2017-08-15 08:14
Publish the Manuscript Online	2017-08-28 06:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Basic Study
Article Title	(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes
Manuscript Source	Invited Manuscript
All Author List	Yi-Zhong Wang, Jie-Liang Li, Xu Wang, Ting Zhang and Wen-Zhe Ho
Funding Agency and Grant Number	Funding Agency Grant Number The National Natural Science Foundation of China 81500449 The Natural Science Foundation of Shanghai 14ZR1434200 Shanghai Municipal Commission of Health and Family Planning 20144Y0175 The Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China 20150909-6 The National Institutes of Health, USA DA022177
Corresponding Author	Ting Zhang, MD, PhD, Department of Infectious Diseases, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai 200040, China. zhangt@shchildren.com.cn
Key Words	(-)-Epigallocatechin-3-gallate; Toll-like receptor 3; Retinoic acid-inducible gene I; IFN-λ1; Hepatitis C virus; IFN-stimulated genes
Core Tip	The interactions between hepatitis C virus (HCV) and the host immune system in the liver play a key role in the immunopathogenesis of HCV-induced diseases. We showed here that (-)-epigallocatechin-3-gallate (EGCG) treatment could significantly increase the poly I:C-induced expression of TLR3, RIG-I and interferon (IFN)-λ1 in JFH-1-Huh7 cells. In addition, supplementation with EGCG enhanced poly I:C-mediated viral inhibition in JFH-1-Huh7 cells at both RNA and protein levels. Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several IFN-stimulated genes. It would be interesting to investigate the possible use of EGCG in combination with current antiviral drugs for HCV therapy.
Publish Date	2017-08-28 06:54
Citation	Wang YZ, Li JL, Wang X, Zhang T, Ho WZ. (-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes. World J Gastroenterol 2017; 23(32): 5895-5903
URL	http://www.wjgnet.com/1007-9327/full/v23/i32/5895.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i32.5895

Full Article (PDF)	WJG-23-5895.pdf
Full Article (Word)	WJG-23-5895.doc
Manuscript File	32366-Review.doc
Answering Reviewers	32366-Answering reviewers.pdf
Audio Core Tip	32366-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32366-Conflict-of-interest statement.pdf
Copyright License Agreement	32366-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32366-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	32366-Language certificate.pdf
Peer-review Report	32366-Peer-review(s).pdf
Scientific Misconduct Check	32366-Scientific misconduct check.pdf
Scientific Editor Work List	32366-Scientific editor work list.pdf