BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/14/2017 9:25:57 AM | Browse: 1199 | Download: 2535
 |
Received |
|
2017-01-06 09:40 |
|
Peer-Review Started |
|
2017-01-09 09:24 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2017-03-07 19:55 |
|
Revised |
|
2017-03-20 16:32 |
|
Publication Fee Transferred |
|
2017-05-05 17:10 |
|
Second Decision by Editor |
|
2017-04-27 17:23 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2017-05-04 18:21 |
|
Articles in Press |
|
2017-05-04 18:21 |
|
Edit the Manuscript by Language Editor |
|
2017-05-09 19:17 |
|
Typeset the Manuscript |
|
2017-06-09 09:32 |
|
Publish the Manuscript Online |
|
2017-06-14 09:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Li Yin, Hong-Li Song, Yang Yang, Wei-Ping Zheng, Tao Liu and Zhong-Yang Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81270528 |
| National Natural Science Foundation of China |
81441022 |
| National Natural Science Foundation of China |
81670574 |
| Natural Science Foundation of Tianjin, China |
08JCYBJC08400 |
| Natural Science Foundation of Tianjin, China |
11JCZDJC27800 |
| The Natural Science Foundation of Tianjin, China |
12JCZDJC25200 |
| Technology Foundation of the Health Bureau in Tianjin, China |
2011KY11 |
|
| Corresponding Author |
Zhong-Yang Shen, MD, PhD, Professor, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192,
China. shenzhy@tmu.edu.cn |
| Key Words |
bone marrow mesenchymal stem cells; CXCR3; HO-1; Small bowel transplantation; Rejection |
| Core Tip |
In this paper, transplant recipient rats were pretreated with bone marrow mesenchymal stem cells (BMMSCs) in advance, and these rats were in a compromised immune state. CXCR3/HO-1 gene modified BMMSCs were injected into recipient rats after small bowel transplantation. The survival time of these rats was significantly prolonged; the number of cells that underwent apoptosis was significantly lower in the CXCR3/HO-1 modified BMMSCs group compared with rats from the HO-1 gene modified BMMSCs group, the native BMMSCs group, and the NS group. Furthermore, the percentage of regulatory T cells was significantly increased. Proinflammatory cytokines (IL-2, IL-6, IL-17, IFN-γ, and TNF-α) were significantly reduced, while anti-inflammatory cytokines (IL-10 and TGF-β) were significantly increased. Our data suggest that BMMSCs modified with the CXCR3 and HO-1 gene can reduce rejection of the small intestine more effectively than HO-1 modified BMMSCs and native BMMSCs. |
| Publish Date |
2017-06-14 09:25 |
| Citation |
Yin ML, Song HL, Yang Y, Zheng WP, Liu T, Shen ZY. Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection. World J Gastroenterol 2017; 23(22): 4016-4038 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i22/4016.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i22.4016 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
