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Articles Published Processes
6/14/2017 9:25:57 AM | Browse: 1045 | Download: 1871
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Received |
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2017-01-06 09:40 |
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Peer-Review Started |
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2017-01-09 09:24 |
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To Make the First Decision |
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2017-03-03 09:00 |
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Return for Revision |
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2017-03-07 19:55 |
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Revised |
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2017-03-20 16:32 |
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Second Decision |
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2017-04-27 17:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-04 18:21 |
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Articles in Press |
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2017-05-04 18:21 |
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Publication Fee Transferred |
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2017-05-05 17:10 |
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Edit the Manuscript by Language Editor |
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2017-05-09 19:17 |
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Typeset the Manuscript |
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2017-06-09 09:32 |
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Publish the Manuscript Online |
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2017-06-14 09:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Li Yin, Hong-Li Song, Yang Yang, Wei-Ping Zheng, Tao Liu and Zhong-Yang Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81270528 |
| National Natural Science Foundation of China |
81441022 |
| National Natural Science Foundation of China |
81670574 |
| Natural Science Foundation of Tianjin, China |
08JCYBJC08400 |
| Natural Science Foundation of Tianjin, China |
11JCZDJC27800 |
| The Natural Science Foundation of Tianjin, China |
12JCZDJC25200 |
| Technology Foundation of the Health Bureau in Tianjin, China |
2011KY11 |
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| Corresponding Author |
Zhong-Yang Shen, MD, PhD, Professor, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192,
China. shenzhy@tmu.edu.cn |
| Key Words |
bone marrow mesenchymal stem cells; CXCR3; HO-1; Small bowel transplantation; Rejection |
| Core Tip |
In this paper, transplant recipient rats were pretreated with bone marrow mesenchymal stem cells (BMMSCs) in advance, and these rats were in a compromised immune state. CXCR3/HO-1 gene modified BMMSCs were injected into recipient rats after small bowel transplantation. The survival time of these rats was significantly prolonged; the number of cells that underwent apoptosis was significantly lower in the CXCR3/HO-1 modified BMMSCs group compared with rats from the HO-1 gene modified BMMSCs group, the native BMMSCs group, and the NS group. Furthermore, the percentage of regulatory T cells was significantly increased. Proinflammatory cytokines (IL-2, IL-6, IL-17, IFN-γ, and TNF-α) were significantly reduced, while anti-inflammatory cytokines (IL-10 and TGF-β) were significantly increased. Our data suggest that BMMSCs modified with the CXCR3 and HO-1 gene can reduce rejection of the small intestine more effectively than HO-1 modified BMMSCs and native BMMSCs. |
| Publish Date |
2017-06-14 09:25 |
| Citation |
Yin ML, Song HL, Yang Y, Zheng WP, Liu T, Shen ZY. Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection. World J Gastroenterol 2017; 23(22): 4016-4038 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i22/4016.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i22.4016 |
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