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5/8/2017 5:42:52 PM | Browse: 874 | Download: 1373
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 32422
Country/Territory United States
Received
2017-01-07 09:25
Peer-Review Started
2017-01-10 14:18
To Make the First Decision
2017-02-17 09:23
Return for Revision
2017-02-17 16:29
Revised
2017-03-04 02:54
Second Decision
2017-03-13 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-24 10:49
Articles in Press
2017-03-24 10:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-02 15:08
Publish the Manuscript Online
2017-05-08 17:42
ISSN 2219-2808 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Retrospective Study
Article Title Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children
Manuscript Source Invited Manuscript
All Author List Vijay Srinivasan, Daniel Pung and Sean P O’Neill
Funding Agency and Grant Number
Funding Agency Grant Number
Russell Raphaely Endowed Chair Funds in Critical Care Medicine, the Children’s Hospital of Philadelphia, Philadelphia, PA 08-005894
Corresponding Author Vijay Srinivasan, MD, FCCM, Department of Anesthesiology and Critical Care Medicine, the Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, United States. srinivasan@email.chop.edu
Key Words Methadone; Withdrawal; Children; Intensive care; Prolonged opioid infusion
Core Tip Critically ill children exposed to prolonged opioid infusions for sedation and analgesia frequently experience withdrawal symptoms when these infusions are discontinued. Conversion to intermittent opioids such as methadone may reduce such withdrawal sym­ptoms, but published studies and guidelines vary widely in terms of dosing and timeframes for such conversions. In this pragmatic analysis of current practice in our institution, we observed wide variation in dosing con­version and timeframes. We observed that it is feasible to convert from intravenous fentanyl infusion directly to enteral methadone within a timeframe of 48 h using a methadone:fentanyl dose conversion ratio of appro­ximately 2.5:1 to minimize withdrawal and reduce need for rescue opioids.
Publish Date 2017-05-08 17:42
Citation Srinivasan V, Pung D, O’Neill SP. Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children. World J Clin Pediatr 2017; 6(2): 110-117
URL http://www.wjgnet.com/2219-2808/full/v6/i2/110.htm
DOI http://dx.doi.org/10.5409/wjcp.v6.i2.110
Full Article (PDF) WJCP-6-110.pdf
Full Article (Word) WJCP-6-110.doc
Manuscript File 32422-Review.doc
Answering Reviewers 32422-Answering reviewers.pdf
Audio Core Tip 32422-Audio core tip.mp3
Biostatistics Review Certificate 32422-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32422-Conflict-of-interest statement.pdf
Copyright License Agreement 32422-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32422-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170107031713.PDF
Institutional Review Board Approval Form or Document 32422-Institutional review board statement.pdf
Peer-review Report 32422-Peer-review(s).pdf
Scientific Misconduct Check 32422-Scientific misconduct check.pdf
Scientific Editor Work List 32422-Scientific editor work list.pdf