Publication Name	World Journal of Clinical Cases
Manuscript ID	32453
Country	Italy

Received	2017-01-09 08:44
Peer-Review Started	2017-01-12 09:49
To Make the First Decision	2017-02-17 09:26
Return for Revision	2017-02-17 17:09
Revised	2017-02-20 02:00
Second Decision	2017-03-02 16:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-13 11:43
Articles in Press	2017-03-13 11:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-09 15:04
Publish the Manuscript Online	2017-05-15 08:56

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Ticagrelor therapy and atrioventricular block: Do we need to worry?
Manuscript Source	Invited Manuscript
All Author List	Elia De Maria, Ambra Borghi, Letizia Modonesi and Stefano Cappelli
Funding Agency and Grant Number
Corresponding Author	Elia De Maria, MD, PhD, Chief of Arrhythmology Lab, Cardiology Unit, Ramazzini Hospital, Via Molinari 1, 41012 Carpi (Modena), Italy. e.demaria@inwind.it
Key Words	Ticagrelor; Atrioventricular block
Core Tip	Ticagrelor is a potent, direct antiplatelet agent with rapid onset of action and intense platelet inhibition, indicated in patients with acute coronary syndromes (ACS). Even if well tolerated, some patients experience bradyarrhythmias complications, especially sinus bradycardia and sinus arrest. This effect is usually transient, asymptomatic and not associated with higher incidence of severe atrioventricular block. However, recent articles have described ACS patients with high-degree atrioventricular block requiring drug discontinuation and, in some cases, pacemaker implantation. In this paper, we describe and discuss five published reports and two other cases managed in our Hospital. We conclude that, although rarely, ticagrelor can be associated with life-threatening atrioventricular block. Caution and careful monitoring are required especially in patients with already compromised conduction system and/or treated with atrioventricular blocking agents. Future studies, with long-term rhythm monitoring, would help to define the outcome of patients at higher risk of developing this complication.
Publish Date	2017-05-15 08:56
Citation	De Maria E, Borghi A, Modonesi L, Cappelli S. Ticagrelor therapy and atrioventricular block: Do we need to worry? World J Clin Cases 2017; 5(5): 178-182
URL	http://www.wjgnet.com/2307-8960/full/v5/i5/178.htm
DOI	http://dx.doi.org/10.12998/wjcc.v5.i5.178

Full Article (PDF)	WJCC-5-178.pdf
Full Article (Word)	WJCC-5-178.doc
Manuscript File	32453-Review.doc
Answering Reviewers	32453-Answering reviewers.pdf
Audio Core Tip	32453-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32453-Conflict-of-interest statement.pdf
Copyright License Agreement	32453-Copyright assignment.pdf
Peer-review Report	32453-Peer-review(s).pdf
Scientific Misconduct Check	32453-Scientific misconduct check.pdf
Scientific Editor Work List	32453-Scientific editor work list.pdf