Publication Name	World Journal of Gastroenterology
Manuscript ID	32464
Country	China

Received	2017-01-10 08:56
Peer-Review Started	2017-01-10 09:29
To Make the First Decision	2017-02-09 08:50
Return for Revision	2017-02-14 11:06
Revised	2017-02-21 01:08
Second Decision	2017-03-24 12:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-31 07:55
Articles in Press	2017-03-31 07:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-04-19 08:17
Typeset the Manuscript	2017-05-18 04:54
Publish the Manuscript Online	2017-05-27 00:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	M2-like Kupffer cells in fibrotic liver may protect against acute insult
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Fen Zheng, Li Bai, Zhong-Ping Duan, Yuan-Ping Han, Su-Jun Zheng, Yu Chen and Jian-Sheng Li
Funding Agency and Grant Number	Funding Agency Grant Number Special Fund of Clinical Medicine, Beijing Municipal Administration of Hospitals XM201308 Ascent Plan of Beijing Municipal Administration of Hospitals DFL20151601 YouAn Fund for Liver Diseases and AIDS YNKT20160012 Startup Fund from Sichuan University, Beijing Municipal Science and Technology Commission Z131107002213019 Startup Fund from Sichuan University, Beijing Municipal Science and Technology Commission Z151100004015066 Basic-Clinical Cooperation Project of Capital Medical University 17JL47
Corresponding Author	Jian-Sheng Li, Professor, Department of Gastroenterology, First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou 450052, Henan Province, China. lijiansheng@medmail.com.cn
Key Words	Liver fibrosis; Injury resistance; Kupffer cell activation; high-mobility group box 1; Translocation
Core Tip	The hepatoprotective effect conferred by liver fibrosis against acute liver injury is an in­teresting phenomenon, which has not yet been fully characterized. In the present study, we dissected the underlying mechanism of acute injury in the setting of liver fibrosis through investigating the correlation between KC activation and HMGB1 translocation. Our study showed that liver fibrosis protects mice against D-GalN/LPS challenge, and M2-like KCs in the fibrotic liver may exert a protective effect by inhibiting the translocation of HMGB1, a potent pro-inflammatory mediator.
Publish Date	2017-05-27 00:33
Citation	Zheng QF, Bai L, Duan ZP, Han YP, Zheng SJ, Chen Y, Li JS. M2-like Kupffer cells in fibrotic liver may protect against acute insult. World J Gastroenterol 2017; 23(20): 3655-3663
URL	http://www.wjgnet.com/1007-9327/full/v23/i20/3655.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i20.3655

Full Article (PDF)	WJG-23-3655.pdf
Full Article (Word)	WJG-23-3655.doc
Manuscript File	32464-Review.doc
Answering Reviewers	32464-Answering reviewers.pdf
Audio Core Tip	32464-Audio core tip.mp3
Biostatistics Review Certificate	32464-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32464-Conflict-of-interest statement.pdf
Copyright License Agreement	32464-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32464-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	32464-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	32464-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32464-Language certificate.pdf
Peer-review Report	32464-Peer-review(s).pdf
Scientific Misconduct Check	32464-Scientific misconduct check.pdf
Scientific Editor Work List	32464-Scientific editor work list.pdf