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Articles Published Processes
4/6/2017 6:30:00 PM | Browse: 1060 | Download: 2206
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Received |
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2017-01-10 08:38 |
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Peer-Review Started |
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2017-01-10 16:58 |
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To Make the First Decision |
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2017-02-23 09:18 |
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Return for Revision |
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2017-02-24 18:39 |
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Revised |
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2017-02-27 20:04 |
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Second Decision |
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2017-03-03 16:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-06 16:58 |
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Articles in Press |
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2017-03-06 16:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-03-17 01:29 |
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Typeset the Manuscript |
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2017-03-27 15:34 |
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Publish the Manuscript Online |
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2017-04-06 18:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Hua Wu, Jia-Pei Guo, Jun Shi, Hui Wang, Lei-Lei Li, Bin Guo, Dian-Xing Liu, Qing Cao and Zhi-Yong Yuan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hebei Province, China |
H2016209007 |
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| Corresponding Author |
Dr. Zhi-Yong Yuan, Professor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Huanhu West Road, Tianjin 300000, China. tswujinghua@163.com |
| Key Words |
Hepatocellular carcinoma; Radioresistance; chaperone-mediated autophagy; HMGB1; p53 |
| Core Tip |
The activation of chaperone-mediated autophagy plays an important role in reducing hepatocellular carcinoma (HCC) cell apoptosis in response to irradiation through degraded HMGB1 protein which reduces p53 expression. The discovery of this mechanism will be beneficial for inhibiting radioresistance of HCC and has a promising value in clinical treatment strategy. |
| Publish Date |
2017-04-06 18:30 |
| Citation |
Wu JH, Guo JP, Shi J, Wang H, Li LL, Guo B, Liu DX, Cao Q, Yuan ZY. CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World J Gastroenterol 2017; 23(13): 2308-2317 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i13/2308.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i13.2308 |
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