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4/6/2017 6:30:00 PM | Browse: 186 | Download: 740
Publication Name World Journal of Gastroenterology
Manuscript ID 32474
Country of Manuscript Source China
2017-01-10 08:38
Peer-Review Started
2017-01-10 16:58
To Make the First Decision
2017-02-23 09:18
Return for Revision
2017-02-24 18:39
2017-02-27 20:04
Second Decision
2017-03-03 16:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-06 16:58
Articles in Press
2017-03-06 16:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-03-17 01:29
Typeset the Manuscript
2017-03-27 15:34
Publish the Manuscript Online
2017-04-06 18:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jing-Hua Wu, Jia-Pei Guo, Jun Shi, Hui Wang, Lei-Lei Li, Bin Guo, Dian-Xing Liu, Qing Cao and Zhi-Yong Yuan
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Hebei Province, China H2016209007
Correspondence To Dr. Zhi-Yong Yuan, Professor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Huanhu West Road, Tianjin 300000, China. tswujinghua@163.com
Keywords Hepatocellular carcinoma; Radioresistance; chaperone-mediated autophagy; HMGB1; p53
Core Tip The activation of chaperone-mediated autophagy plays an important role in reducing hepatocellular carcinoma (HCC) cell apoptosis in response to irradiation through degraded HMGB1 protein which reduces p53 expression. The discovery of this mechanism will be beneficial for inhibiting radioresistance of HCC and has a promising value in clinical treatment strategy.
Publish Date 2017-04-06 18:30
Citation Wu JH, Guo JP, Shi J, Wang H, Li LL, Guo B, Liu DX, Cao Q, Yuan ZY. CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World J Gastroenterol 2017; 23(13): 2308-2317
Url http://www.wjgnet.com/1007-9327/full/v23/i13/2308.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i13.2308
Full Article (PDF) WJG-23-2308.pdf
Full Article (Word) WJG-23-2308.doc
Revised Manuscript 32474-Review.doc
Peer-review Report 32474-Peer-review(s).pdf
Answering Reviewers 32474-Answering reviewers.pdf
Scientific Misconduct Check 32474-Scientific misconduct check.pdf
Scientific Editor Work List 32474-Scientific editor work list.pdf
Audio Core Tip 32474-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32474-Conflict-of-interest statement.pdf
Copyright License Agreement 32474-Copyright assignment.pdf
Data Sharing Statement 32474-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32474-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32474-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 32474-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32474-Language certificate.pdf
Scientific Research Process 32474-Scientific research process.pdf