Publication Name	World Journal of Gastroenterology
Manuscript ID	32488
Country	Netherlands

Received	2017-01-11 09:12
Peer-Review Started	2017-01-12 08:59
To Make the First Decision	2017-02-23 09:18
Return for Revision	2017-02-27 10:11
Revised	2017-03-13 04:56
Second Decision	2017-04-11 16:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-12 17:59
Articles in Press	2017-04-12 17:59
Publication Fee Transferred	2017-06-20 06:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-26 01:49
Publish the Manuscript Online	2017-07-07 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Management and outcome of hepatocellular adenoma with massive bleeding at presentation
Manuscript Source	Unsolicited Manuscript
All Author List	Anne J Klompenhouwer, Robert A de Man, Maarten GJ Thomeer and Jan NM IJzermans
Funding Agency and Grant Number
Corresponding Author	Jan NM IJzermans, MD, PhD, Professor, Department of Surgery, Erasmus MC, Rotterdam 3000 CA, the Netherlands. j.ijzermans@erasmusmc.nl
Key Words	Hepatocellular adenoma; Management; Bleeding; Outcome; Hemorrhage
Core Tip	As massive bleeding due to ruptured hepatocellular adenoma (HCA) is rare, we present a unique series of 23 consecutive patients. To our knowledge, this is the first study to assess the outcome and sequelae of the massive bleeding complication, including risk of rebleeding and need for elective tumor resection. In our series, risk of rebleeding was 4.3% and most HCAs regressed spontaneously. No long-term complications were documented. These cases suggest that a wait-and-watch policy may be legitimate and secondary (elective) treatment may only be considered for persistent HCA > 5 cm after follow-up and/or for patients with desire for future pregnancy.
Publish Date	2017-07-07 11:41
Citation	Klompenhouwer AJ, de Man RA, Thomeer MGJ, Ijzermans JNM. Management and outcome of hepatocellular adenoma with massive bleeding at presentation. World J Gastroenterol 2017; 23(25): 4579-4586
URL	http://www.wjgnet.com/1007-9327/full/v23/i25/4579.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i25.4579

Full Article (PDF)	WJG-23-4579.pdf
Full Article (Word)	WJG-23-4579.doc
Manuscript File	32488-Review.docx
Answering Reviewers	32488-Answering reviewers.pdf
Audio Core Tip	32488-Audio core tip.mp3
Biostatistics Review Certificate	32488-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20170110181639.docx
Conflict-of-Interest Disclosure Form	32488-Conflict-of-interest statement.pdf
Copyright License Agreement	32488-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20170110181453.docx
Institutional Review Board Approval Form or Document	32488-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32488-Language certificate.pdf
Peer-review Report	32488-Peer-review(s).pdf
Scientific Misconduct Check	32488-Scientific misconduct check.pdf
Scientific Editor Work List	32488-Scientific editor work list.pdf