| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Wang, Mei Liu, Su-Jun Zheng, Dan-Dan Bian, Jin-Yan Zhang, Jia Yao, Qing-Fen Zheng, A-Meng Shi, Wen-Han Li, Lu Li, Yu Chen, Jin-Hai Wang, Zhong-Ping Duan and Lei Dong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Clinical Research Cooperation Fund of the Capital Medical University |
15JL67 |
| Project of Science and Technology Development Plan of Beijing Municipal Education Commission |
KM201610025021 |
| High-Tech Personnel Training Program of Beijing Health System |
2015-3-104, 2013-3-071 |
| Beijing Municipal Science & Technology Commission |
No.Z151100004015066 |
| Shaanxi Science and Technology Coordination and Innovation Project |
2016KTZDSF02-02 |
|
| Corresponding Author |
Dr. Lei Dong, Professor, Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China. donglei6655@126.com |
| Key Words |
α-fetoprotein; Nucleophosmin 1; 14-3-3zeta; Mouse double minute 2 homolog; Immunodiagnosis; Autoantibody; Hepatocellular carcinoma |
| Core Tip |
We firstly and specifically investigated the diagnostic value of autoantibodies in α-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). We retrospectively evaluated the prevalence and diagnostic value of autoantibodies to nucleophosmin (NPM)1, 14-3-3zeta and mouse double minute 2 homolog (MDM2) proteins and their different combinations in 56 AFP-negative HCC patients by enzyme-linked immunosorbent assay and western blotting. Immunohistochemistry was used to detect the expression of three tumor-associated antigens (TAAs) in AFP-negative HCC. Our study demonstrated that autoantibodies to NPM1, 14-3-3zeta and MDM2 may be useful biomarkers for immunodiagnosis of AFP-negative HCC. |
| Publish Date |
2017-05-20 12:26 |
| Citation |
Wang T, Liu M, Zheng SJ, Bian DD, Zhang JY, Yao J, Zheng QF, Shi AM, Li WH, Li L, Chen Y, Wang JH, Duan ZP, Dong L. Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma. World J Gastroenterol 2017; 23(19): 3496-3504 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i19/3496.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i19.3496 |
