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5/20/2017 12:26:24 PM | Browse: 495 | Download: 575
Publication Name World Journal of Gastroenterology
Manuscript ID 32489
Country of Manuscript Source China
2017-01-11 08:56
Peer-Review Started
2017-01-11 10:12
To Make the First Decision
2017-02-09 08:52
Return for Revision
2017-02-14 11:17
2017-02-21 11:27
Second Decision
2017-03-24 12:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-31 07:56
Articles in Press
2017-03-31 07:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-04-16 02:03
Typeset the Manuscript
2017-05-08 11:56
Publish the Manuscript Online
2017-05-20 12:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Cohort Study
Article Title Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Ting Wang, Mei Liu, Su-Jun Zheng, Dan-Dan Bian, Jin-Yan Zhang, Jia Yao, Qing-Fen Zheng, A-Meng Shi, Wen-Han Li, Lu Li, Yu Chen, Jin-Hai Wang, Zhong-Ping Duan and Lei Dong
Funding Agency and Grant Number
Funding Agency Grant Number
Clinical Research Cooperation Fund of the Capital Medical University 15JL67
Project of Science and Technology Development Plan of Beijing Municipal Education Commission KM201610025021
High-Tech Personnel Training Program of Beijing Health System 2015-3-104, 2013-3-071
Beijing Municipal Science & Technology Commission No.Z151100004015066
Shaanxi Science and Technology Coordination and Innovation Project 2016KTZDSF02-02
Corresponding author Dr. Lei Dong, Professor, Department of Gastroenterology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China. donglei6655@126.com
Keywords α-fetoprotein; Nucleophosmin 1; 14-3-3zeta; Mouse double minute 2 homolog; Immunodiagnosis; Autoantibody; Hepatocellular carcinoma
Core Tip We firstly and specifically investigated the diagnostic value of autoantibodies in α-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). We retrospectively evaluated the prevalence and diagnostic value of autoantibodies to nucleophosmin (NPM)1, 14-3-3zeta and mouse double minute 2 homolog (MDM2) proteins and their different combinations in 56 AFP-negative HCC patients by enzyme-linked immunosorbent assay and western blotting. Immunohistochemistry was used to detect the expression of three tumor-associated antigens (TAAs) in AFP-negative HCC. Our study demonstrated that autoantibodies to NPM1, 14-3-3zeta and MDM2 may be useful biomarkers for immunodiagnosis of AFP-negative HCC.
Publish Date 2017-05-20 12:26
Citation Wang T, Liu M, Zheng SJ, Bian DD, Zhang JY, Yao J, Zheng QF, Shi AM, Li WH, Li L, Chen Y, Wang JH, Duan ZP, Dong L. Tumor-associated autoantibodies are useful biomarkers in immunodiagnosis of α-fetoprotein-negative hepatocellular carcinoma. World J Gastroenterol 2017; 23(19): 3496-3504
Url http://www.wjgnet.com/1007-9327/full/v23/i19/3496.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i19.3496
Full Article (PDF) WJG-23-3496.pdf
Full Article (Word) WJG-23-3496.doc
Manuscript File 32489-Review.doc
Answering Reviewers 32489-Answering reviewers.pdf
Audio Core Tip 32489-Audio core tip.mp3
Biostatistics Review Certificate 32489-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32489-Conflict-of-interest statement.pdf
Copyright License Agreement 32489-Copyright assignment.pdf
Data Sharing Statement 32489-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32489-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170110182045.docx
Institutional Review Board Approval Form or Document 32489-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32489-Language certificate.pdf
Scientific Research Process 32489-Scientific research process.pdf
Peer-review Report 32489-Peer-review(s).pdf
Scientific Misconduct Check 32489-Scientific misconduct check.pdf
Scientific Editor Work List 32489-Scientific editor work list.pdf