Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	3252
Country	United Kingdom

Received	2013-04-17 08:04
Peer-Review Started	2013-04-17 11:57
To Make the First Decision	2013-05-02 10:29
Return for Revision	2013-05-13 13:51
Revised	2013-05-22 03:11
Second Decision	2013-06-19 13:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-20 01:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-26 08:19
Publish the Manuscript Online	2013-08-01 15:35

ISSN	2150-5349 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition
Manuscript Source	Invited Manuscript
All Author List	Ian Leonard Phillip Beales, Abigail Hensley and Yoon Loke
Funding Agency and Grant Number
Corresponding Author	Dr. Ian Leonard Phillip Beales, Clinical Senior Lecturer and Honorary Consultant Gastroenterologist, Department of Gastroenterology, Norfolk and Norwich University Hospital, Colney Ln, Norwich NR4 TJ, United Kingdom. i.beales@uea.ac.uk
Key Words	Aspirin; Barrett’s oesophagus; Chemoprevention; Cancer risk; Esophageal carcinoma; Non-steroidal anti-inflammatory drugs; Statins
Core Tip	Esophageal cancer remains a major burden upon health. The incidence of esophageal adenocarcinoma has increased dramatically in western countries. Experimental studies have suggested that statins may have useful actions against esophageal cancer cells. This systematic review and meta-analysis of observational studies shows that statin use was associated with a reduced incidence of all esophageal cancers (19% decrease). A more striking reduction in adenocarcinoma incidence in patients with Barrett’s esophagus taking statins was seen (43% decrease) and this effect was enhanced in those also taking cyclo-oxygenase inhibitors (74% decrease). This combination offers promise for chemoprevention and further interventional studies are warranted.
Publish Date	2013-08-01 15:35
Citation	Beales ILP, Hensley A, Loke Y. Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition. World J Gastrointest Phar-macol Ther 2013; 4(3): 69-79
URL	http://www.wjgnet.com/2150-5349/full/v4/i3/69.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v4.i3.69

Full Article (PDF)	WJGPT-4-69.pdf
Manuscript File	3252-Review.doc
Answering Reviewers	3252-Answering reviewers.pdf
Copyright License Agreement	3252-Copyright assignment.pdf
Peer-review Report	3252-Peer reviews.pdf
Scientific Editor Work List	3252-Scientific editor work list.doc