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Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 3252
Country of Manuscript Source United Kingdom
Received
2013-04-17 08:04
Peer-Review Started
2013-04-17 11:57
To Make the First Decision
2013-05-02 10:29
Return for Revision
2013-05-13 13:51
Revised
2013-05-22 03:11
Second Decision
2013-06-19 13:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 01:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-06-26 08:19
Publish the Manuscript Online
2013-08-01 15:35
ISSN 2150-5349 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Meta-Analysis
Article Title Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition
Manuscript Source Invited Manuscript
All Author List Ian Leonard Phillip Beales, Abigail Hensley and Yoon Loke
Funding Agency and Grant Number
Corresponding author Dr. Ian Leonard Phillip Beales, Clinical Senior Lecturer and Honorary Consultant Gastroenterologist, Department of Gastroenterology, Norfolk and Norwich University Hospital, Colney Ln, Norwich NR4 TJ, United Kingdom. i.beales@uea.ac.uk
Keywords Aspirin; Barrett’s oesophagus; Chemoprevention; Cancer risk; Esophageal carcinoma; Non-steroidal anti-inflammatory drugs; Statins
Core Tip Esophageal cancer remains a major burden upon health. The incidence of esophageal adenocarcinoma has increased dramatically in western countries. Experimental studies have suggested that statins may have useful actions against esophageal cancer cells. This systematic review and meta-analysis of observational studies shows that statin use was associated with a reduced incidence of all esophageal cancers (19% decrease). A more striking reduction in adenocarcinoma incidence in patients with Barrett’s esophagus taking statins was seen (43% decrease) and this effect was enhanced in those also taking cyclo-oxygenase inhibitors (74% decrease). This combination offers promise for chemoprevention and further interventional studies are warranted.
Publish Date 2013-08-01 15:35
Citation Beales ILP, Hensley A, Loke Y. Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition. World J Gastrointest Phar-macol Ther 2013; 4(3): 69-79
Url http://www.wjgnet.com/2150-5349/full/v4/i3/69.htm
DOI http://dx.doi.org/10.4292/wjgpt.v4.i3.69
Full Article (PDF) WJGPT-4-69.pdf
Manuscript File 3252-Review.doc
Answering Reviewers 3252-Answering reviewers.pdf
Copyright License Agreement 3252-Copyright assignment.pdf
Peer-review Report 3252-Peer reviews.pdf
Scientific Editor Work List 3252-Scientific editor work list.doc