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Articles Published Processes
7/7/2017 11:41:16 AM | Browse: 1060 | Download: 2019
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Received |
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2017-01-13 09:04 |
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Peer-Review Started |
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2017-01-14 10:58 |
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To Make the First Decision |
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2017-02-09 13:18 |
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Return for Revision |
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2017-02-14 10:54 |
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Revised |
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2017-02-24 21:00 |
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Second Decision |
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2017-03-03 16:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-06 17:00 |
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Articles in Press |
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2017-03-06 17:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-05-23 19:28 |
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Typeset the Manuscript |
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2017-06-21 11:07 |
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Publish the Manuscript Online |
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2017-07-07 11:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Paloma Muñoz de Rueda, José Manuel Fuentes Rodríguez, Rosa Quiles Pérez, Ana Gila Medina, Ana Belén Martín Álvarez, Jorge Casado Ruíz, Ángeles Ruíz Extremera and Javier Salmerón |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Consejería de Salud de la Junta de Andalucía” |
PI0137/07 |
| “Instituto de Salud Carlos III” |
FIS-Intrasalud PI010/717 |
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| Corresponding Author |
Rosa Quiles, CIBERehd Researcher, Instituto de Investigación Biosanitaria de Granada, Research Support Unit, University Hospital San Cecilio of Granada, Dr/ Olóriz 16, 18012, Granada, Spain. rosa-quiles@hotmail.com |
| Key Words |
Interferon-based therapy; Interferon-free therapy; Chronic hepatitis C; NS5A region; Sustained virological response; Number of mutations |
| Core Tip |
To the best of our knowledge, this study is the first to evaluate the change in the number of mutations of the hepatitis C virus (HCV) NS5A region in patients with chronic hepatitis C genotype 1 and who were non-responders to two or more treatments over a period of two decades. The number of mutations in the HCV NS5A region was identified as an independent predictor of a sustained virological response regardless of the interferon-containing regimen or direct-acting antiviral-containing interferon-free protocol applied. |
| Publish Date |
2017-07-07 11:41 |
| Citation |
Muñoz de Rueda P, Fuentes Rodríguez JM, Quiles Pérez R, Gila Medina A, Martín Álvarez AB, Casado Ruíz J, Ruíz Extremera A, Salmerón J. Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment. World J Gastroenterol 2017; 23(25): 4538-4547 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i25/4538.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i25.4538 |
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