Publication Name	World Journal of Gastroenterology
Manuscript ID	32539
Country	Germany

Received	2017-01-13 08:58
Peer-Review Started	2017-01-14 11:15
To Make the First Decision	2017-02-23 09:18
Return for Revision	2017-02-27 10:32
Revised	2017-04-05 00:08
Second Decision	2017-05-05 08:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-09 16:56
Articles in Press	2017-05-09 16:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-07 09:01
Publish the Manuscript Online	2017-06-14 09:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells
Manuscript Source	Invited Manuscript
All Author List	Svenja Sydor, Sami Jafoui, Lena Wingerter, Sandra Swoboda, Joachim C Mertens, Guido Gerken, Ali Canbay, Andreas Paul and Christian D Fingas
Funding Agency and Grant Number	Funding Agency Grant Number DFG/German Research Foundation FI 1630/3-1 DFG/German Research Foundation IFORES D/107 114400 (to CDF)
Corresponding Author	Christian D Fingas, MD, PhD, Associate Professor, Department for General, Visceral and Transplantation Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany. christian.fingas@uk-essen.de
Key Words	Tumor necrosis factor-related apoptosis-inducing ligand; Myeloid cell leukemia-1; Hedgehog pathway; Cisplatin; Chemotherapy resistance
Core Tip	This manuscript addresses the timely and topical roles of cell cycle/apoptosis modulating enzymes for the tumor biology of human cholangiocarcinoma. These data suggest that polo-like kinases -Inhibition by BI6727 (volasertib) sensitizes some cholangiocarcinoma cell lines to cisplatin-induced apoptosis. Our findings include an enhanced cytotoxic effect of cisplatin by co-treatment with BI6727 (volasertib) and results in decreased protein expression levels of the anti-apoptotic molecule Bcl-2, which appears to be mediated via proteasomal degradation. Taken together, these data reveal another pro-apoptotic mechanism of polo-like kinase inhibition emphasizing the potential therapeutic benefit of polo-like kinase inhibitors for the treatment of cholangiocarcinoma.
Publish Date	2017-06-14 09:25
Citation	Sydor S, Jafoui S, Wingerter L, Swoboda S, Mertens JC, Gerken G, Canbay A, Paul A, Fingas CD. Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells. World J Gastroenterol 2017; 23(22): 4007-4015
URL	http://www.wjgnet.com/1007-9327/full/v23/i22/4007.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i22.4007

Full Article (PDF)	WJG-23-4007.pdf
Full Article (Word)	WJG-23-4007.doc
Manuscript File	32539-Review.docx
Answering Reviewers	32539-Answering reviewers.pdf
Audio Core Tip	32539-Audio core tip.mp3
Biostatistics Review Certificate	32539-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32539-Conflict-of-interest statement.pdf
Copyright License Agreement	32539-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32539-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	32539-Language certificate.pdf
Peer-review Report	32539-Peer-review(s).pdf
Scientific Misconduct Check	32539-Scientific misconduct check.pdf
Scientific Editor Work List	32539-Scientific editor work list.pdf