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6/14/2017 9:25:57 AM | Browse: 771 | Download: 1703
Publication Name World Journal of Gastroenterology
Manuscript ID 32539
Country/Territory Germany
Received
2017-01-13 08:58
Peer-Review Started
2017-01-14 11:15
To Make the First Decision
2017-02-23 09:18
Return for Revision
2017-02-27 10:32
Revised
2017-04-05 00:08
Second Decision
2017-05-05 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-09 16:56
Articles in Press
2017-05-09 16:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-07 09:01
Publish the Manuscript Online
2017-06-14 09:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells
Manuscript Source Invited Manuscript
All Author List Svenja Sydor, Sami Jafoui, Lena Wingerter, Sandra Swoboda, Joachim C Mertens, Guido Gerken, Ali Canbay, Andreas Paul and Christian D Fingas
Funding Agency and Grant Number
Funding Agency Grant Number
DFG/German Research Foundation FI 1630/3-1
DFG/German Research Foundation IFORES D/107 114400 (to CDF)
Corresponding Author Christian D Fingas, MD, PhD, Associate Professor, Department for General, Visceral and Transplantation Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany. christian.fingas@uk-essen.de
Key Words Tumor necrosis factor-related apoptosis-inducing ligand; Myeloid cell leukemia-1; Hedgehog pathway; Cisplatin; Chemotherapy resistance
Core Tip This manuscript addresses the timely and topical roles of cell cycle/apoptosis modulating enzymes for the tumor biology of human cholangiocarcinoma. These data suggest that polo-like kinases -Inhibition by BI6727 (volasertib) sensitizes some cholangiocarcinoma cell lines to cisplatin-induced apoptosis. Our findings include an enhanced cytotoxic effect of cisplatin by co-treatment with BI6727 (volasertib) and results in decreased protein expression levels of the anti-apoptotic molecule Bcl-2, which appears to be mediated via proteasomal degradation. Taken together, these data reveal another pro-apoptotic mechanism of polo-like kinase inhibition emphasizing the potential therapeutic benefit of polo-like kinase inhibitors for the treatment of cholangiocarcinoma.
Publish Date 2017-06-14 09:25
Citation Sydor S, Jafoui S, Wingerter L, Swoboda S, Mertens JC, Gerken G, Canbay A, Paul A, Fingas CD. Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells. World J Gastroenterol 2017; 23(22): 4007-4015
URL http://www.wjgnet.com/1007-9327/full/v23/i22/4007.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i22.4007
Full Article (PDF) WJG-23-4007.pdf
Full Article (Word) WJG-23-4007.doc
Manuscript File 32539-Review.docx
Answering Reviewers 32539-Answering reviewers.pdf
Audio Core Tip 32539-Audio core tip.mp3
Biostatistics Review Certificate 32539-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32539-Conflict-of-interest statement.pdf
Copyright License Agreement 32539-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32539-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 32539-Language certificate.pdf
Peer-review Report 32539-Peer-review(s).pdf
Scientific Misconduct Check 32539-Scientific misconduct check.pdf
Scientific Editor Work List 32539-Scientific editor work list.pdf