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Articles Published Processes
6/2/2017 5:29:41 AM | Browse: 1170 | Download: 1868
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Received |
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2017-01-13 08:40 |
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Peer-Review Started |
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2017-01-16 11:13 |
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To Make the First Decision |
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2017-02-17 08:59 |
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Return for Revision |
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2017-02-20 14:33 |
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Revised |
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2017-03-06 01:24 |
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Second Decision |
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2017-04-10 18:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-04-20 08:46 |
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Articles in Press |
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2017-04-20 08:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-26 04:57 |
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Publish the Manuscript Online |
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2017-06-02 05:29 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cynthia I Tchio Mantho, Adriana Harbuzariu and Ruben R Gonzalez-Perez |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Defense (DoD) office of the Congressionally Directed Medical Research Programs (CDMRP) |
DODXWH-13-1-0382 |
| NIH/NCI |
1R41CA183399-01A1 |
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| Corresponding Author |
Dr. Ruben R Gonzalez-Perez, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Hugh Gloster Bldg., Room 329, Atlanta, GA 30310, United States. rgonzalez@msm.edu |
| Key Words |
Pancreatic Cancer; MicroRNA; Histone deacetylases; Pancreatic cancer stem cell markers; Leptin; Obesity |
| Core Tip |
Pancreatic cancer has no targeted therapy. Obesity is a risk factor for pancreatic cancer, characterized by high levels of leptin. In this review, we discuss the potential crosstalk between histone deacetylases, microRNA, and leptin in disease progression. Crosstalk among these molecules increases proliferation, survival, cancer stem cells and resistance to chemotherapy. The potential relationships between these molecules are analyzed using data from the Cancer Genome Atlas and the Pathway Studio Platform. The crosstalk among these molecules could be a novel target for pancreatic cancer prevention or treatment, particularly in obese patients that show elevated levels of leptin. |
| Publish Date |
2017-06-02 05:29 |
| Citation |
Tchio Mantho CI, Harbuzariu A, Gonzalez-Perez RR. Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer. World J Clin Oncol 2017; 8(3): 178-189 |
| URL |
http://www.wjgnet.com/2218-4333/full/v8/i3/178.htm |
| DOI |
http://dx.doi.org/10.5306/wjco.v8.i3.178 |
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