Publication Name	World Journal of Gastroenterology
Manuscript ID	32644
Country	Italy

Received	2017-01-18 10:23
Peer-Review Started	2017-01-19 19:40
To Make the First Decision	2017-02-09 15:03
Return for Revision	2017-02-14 11:50
Revised	2017-03-07 23:47
Second Decision	2017-04-27 17:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-04 18:26
Articles in Press	2017-05-04 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-19 02:26
Publish the Manuscript Online	2017-05-27 00:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Retrospective Cohort Study
Article Title	Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Daniele Nicolini, Andrea Agostini, Roberto Montalti, Federico Mocchegiani, Cinzia Mincarelli, Alessandra Mandolesi, Nicola L Robertson, Roberto Candelari, Andrea Giovagnogni and Marco Vivarelli
Funding Agency and Grant Number
Corresponding Author	Daniele Nicolini, MD, PhD, Division of Hepatobiliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, via Tronto n°10/a, 60126 Ancona, Italy. daniele.nicolini@ospedaliriuniti.marche.it
Key Words	Liver transplantation; Recurrence-free survival; Hepatocellular carcinoma; Radiological response; Locoregional therapies; Inflammatory markers; Selection criteria
Core Tip	The response to loco-regional therapy and biological markers appear to stratify the prognosis of hepatocellular carcinoma patients awaiting liver transplantation (LT) better than morphological criteria; however, their role in the selection scheme still needs validation. We analysed a homogeneous cohort of 70 patients treated exclusively by transarterial chemoembolization (TACE) prior to LT; the radiological response was assessed by two different enhancing methods (mRECIST and EASL criteria) that provided an accurate preoperative estimation of histological necrosis. We also demonstrated that a lack of response to TACE and a high platelet-to-lymphocyte ratio before surgery are strongly predictive of tumour recurrence, independently of the Milan criteria status at referral.
Publish Date	2017-05-27 00:33
Citation	Nicolini D, Agostini A, Montalti R, Mocchegiani F, Mincarelli C, Mandolesi A, Robertson NL, Candelari R, Giovagnoni A, Vivarelli M. Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation. World J Gastroenterol 2017; 23(20): 3690-3701
URL	http://www.wjgnet.com/1007-9327/full/v23/i20/3690.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i20.3690

Full Article (PDF)	WJG-23-3690.pdf
Full Article (Word)	WJG-23-3690.doc
Manuscript File	32644-Review.docx
Answering Reviewers	32644-Answering reviewers.pdf
Audio Core Tip	32644-Audio core tip.m4a
Biostatistics Review Certificate	32644-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32644-Conflict-of-interest statement.pdf
Copyright License Agreement	32644-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	32644-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	32644-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32644-Language certificate.pdf
Peer-review Report	32644-Peer-review(s).pdf
Scientific Misconduct Check	32644-Scientific misconduct check.pdf
Scientific Editor Work List	32644-Scientific editor work list.pdf