Publication Name	World Journal of Hepatology
Manuscript ID	32659
Country	Singapore

Received	2017-01-18 20:31
Peer-Review Started	2017-01-20 20:02
To Make the First Decision	2017-03-13 17:46
Return for Revision	2017-03-16 19:10
Revised	2017-03-24 14:04
Second Decision	2017-06-08 07:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-13 04:57
Articles in Press	2017-06-13 04:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-27 09:01
Publish the Manuscript Online	2017-08-07 06:12

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Low serum albumin predicts early mortality in patients with severe hypoxic hepatitis
Manuscript Source	Invited Manuscript
All Author List	Pik-Eu Chang, Boon-Bee George Goh, Victoria Ekstrom, Ming-Liang Ong and Chee-Kiat Tan
Funding Agency and Grant Number
Corresponding Author	Chee-Kiat Tan, MBBS(NUS), MRCP(UK), FRCP(Edinburgh), Associate Professor, Department of Gastroenterology and Hepatology, Singapore General Hospital, Academia, 20 College Road, Level 3, Singapore 169856, Singapore. tan.chee.kiat@singhealth.com.sg
Key Words	Severe; Mortality; Albumin; Incidence; Hypoxic hepatitis; Predictors; Etiology; Prognosis
Core Tip	Hypoxic hepatitis is an important cause of liver injury that is associated with a high mortality rate. We sought to evaluate the incidence, etiology and predictors of mortality of severe hypoxic hepatitis in a large tertiary-level hospital in Singapore. Our findings confirm that the prevalence and mortality rate of severe hypoxic hepatitis in Asians is consistent with previous studies. Importantly, the unique finding from our study is that low serum albumin level is an independent predictive factor for mortality in severe hypoxic hepatitis, with a five-fold increase in risk of death in patients with serum albumin less than 28 g/L.
Publish Date	2017-08-07 06:12
Citation	Chang PE, Goh BBG, Ekstrom V, Ong ML, Tan CK. Low serum albumin predicts early mortality in patients with severe hypoxic hepatitis. World J Hepatol 2017; 9(22): 959-966
URL	http://www.wjgnet.com/1948-5182/full/v9/i22/959.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i22.959

Full Article (PDF)	WJH-9-959.pdf
Full Article (Word)	WJH-9-959.doc
Manuscript File	32659-Review.docx
Answering Reviewers	32659-Answering reviewers.pdf
Audio Core Tip	32659-Audio core tip.mp3
Biostatistics Review Certificate	32659-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32659-Conflict-of-interest statement.pdf
Copyright License Agreement	32659-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	32659-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	32659-Institutional review board statement.pdf
Peer-review Report	32659-Peer-review(s).pdf
Scientific Misconduct Check	32659-Scientific misconduct check.pdf
Scientific Editor Work List	32659-Scientific editor work list.pdf