| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Guo-Gang Li, Lan Li, Chao Li, Long-Yun Ye, Xiao-Wen Li, Da-Ren Liu, Qi Bao, Yi-Xiong Zheng, Da-Peng Xiang, Li Chen and Jian Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of Science and Technology of Zhejiang Province, China |
2009C14017 |
| National Natural Science Foundation of China |
81071959 |
| National Natural Science Foundation of China |
81101837 |
| Zhejiang Provincial Medical and Healthy Science Foundation of China |
2013KYA100 |
| Zhejiang Provincial Medical and Healthy Science Foundation of China |
2009B043 |
| Public Welfare Technology Research Project of Zhejiang Province,, China |
2010C34001 |
|
| Corresponding Author |
Dr. Jian Chen, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. chenjian_zju@163.com
|
| Key Words |
Gastric cancer; Delta-like ligand 4/Notch; Matrix metalloproteinase; Migration; Invasion |
| Core Tip |
Delta-like ligand 4 (DLL4), one of the five notch signaling ligands in mammals, has been researched mainly with regard to vasculogenesis and tumor angiogenesis. To the best of our knowledge, there is rare study to investigate its role and mechanism in human gastric cancers. We found that DLL4 promotes cellular proliferation, migration, invasion and tumorigenicity in gastric cancer cells. Furthermore, increased mRNA level and increased secretion of matrix metalloproteinase-2 proenzyme, while increased matrix metalloproteinase (MMP)-9 mRNA levels but decreased extracellular MMP-9 proenzyme levels were observed. These results indicated a mechanism by which activation of DLL4-mediated Notch signaling promotes the expression and secretion of MMP-2 proenzyme and influences the progress of gastric cancer.
|
| Publish Date |
2013-07-29 11:18 |
| Citation |
Li GG, Li L, Li C, Ye LY, Li XW, Liu DR, Bao Q, Zheng YX, Xiang DP, Chen L, Chen J. Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells. World J Gastroenterol 2013; 19(28): 4486-4494 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i28/4486.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i28.4486 |
