Publication Name	World Journal of Gastroenterology
Manuscript ID	32794
Country	United States

Received	2017-01-23 08:57
Peer-Review Started	2017-01-27 20:49
To Make the First Decision	2017-02-23 10:25
Return for Revision	2017-02-27 15:27
Revised	2017-03-11 04:44
Second Decision	2017-04-14 17:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-21 15:18
Articles in Press	2017-04-21 15:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-04 10:46
Publish the Manuscript Online	2017-05-15 06:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Risk of progression of Barrett's esophagus in patients with cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Tehilla Apfel, Rocio Lopez, Madhusudhan R Sanaka and Prashanthi N Thota
Funding Agency and Grant Number
Corresponding Author	Prashanthi N Thota, MD, FACG, Director, Esophageal Center, Department of Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, United States. thotap@ccf.org
Key Words	Liver cirrhosis; Barrett’s esophagus; Dysplasia; Esophageal neoplasm; Progression
Core Tip	Fifty seven cirrhotic patients with Barrett’s esophagus (BE) were compared to 228 non-cirrhotic BE controls. Nonalcoholic steatohepatitis or cardiac cirrhosis was the most common causes of cirrhosis in this group. There were no differences in incidence rates of high-grade dysplasia (HGD)/esophageal adenocarcinoma (EAC) in nondysplastic BE between cirrhotic cases and noncirrhotic controls (1.4 vs 1.1 per 100 person -years, P = 0.8). In low grade dysplasia, cirrhotic patients were found to have higher rates of progression to HGD/EAC compared to control group though this did not reach statistical significance (13.7 vs 8.1 per 100 person- years, P = 0.51). There was approximately 8 times increased risk of progression for every one point increase in Child- Pugh class.
Publish Date	2017-05-15 06:16
Citation	Apfel T, Lopez R, Sanaka MR, Thota PN. Risk of progression of Barrett’s esophagus in patients with cirrhosis. World J Gastroenterol 2017; 23(18): 3287-3294
URL	http://www.wjgnet.com/1007-9327/full/v23/i18/3287.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i18.3287

Full Article (PDF)	WJG-23-3287.pdf
Full Article (Word)	WJG-23-3287.doc
Manuscript File	32794-Review.docx
Answering Reviewers	32794-Answering reviewers.pdf
Audio Core Tip	32794-Audio core tip.wma
Biostatistics Review Certificate	32794-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32794-Conflict-of-interest statement.pdf
Copyright License Agreement	32794-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	32794-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	32794-Institutional review board statement.pdf
Peer-review Report	32794-Peer-review(s).pdf
Scientific Misconduct Check	32794-Scientific misconduct check.pdf
Scientific Editor Work List	32794-Scientific editor work list.pdf