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6/7/2017 7:22:42 AM | Browse: 953 | Download: 1343
Publication Name World Journal of Gastroenterology
Manuscript ID 32796
Country/Territory Australia
Received
2017-01-25 19:42
Peer-Review Started
2017-01-27 20:50
To Make the First Decision
2017-03-03 10:08
Return for Revision
2017-03-06 17:19
Revised
2017-03-13 09:59
Second Decision
2017-04-27 11:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-04 18:43
Articles in Press
2017-05-04 18:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-25 08:48
Publish the Manuscript Online
2017-06-07 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats
Manuscript Source Invited Manuscript
All Author List Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Lang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu and Xian-Qin Qu
Funding Agency and Grant Number
Corresponding Author Xian-Qin Qu, PhD, MD, School of Medical and Molecular Biosciences, University of Technology Sydney, 15 Broadway, NSW 2007, Australia. xianqin.qu@uts.edu.au
Key Words Non-alcoholic fatty liver disease; Green tea polyphenols; Hepatic lipogenesis; Inflammatory cytokines; AMP-activated protein kinase
Core Tip The aim of this study was to examine the protective effects and molecular mechanism of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD)-induced by high fat diet (HFD) in genetically obese Zucker fatty (ZF) rats. The data of the study has demonstrated: (1) HFD-ZF rats is an optimal rodent model of NAFLD for testing novel/natural agents for this disease; (2) GTP treatment ameliorated metabolic and histopathological abnormalities in HFD-ZF rats with NAFLD; and (3) GTP exerted a protective effect against hepatic steatosis and liver injury by attenuating inflammatory cytokines and inhibiting lipogenesis through upregulating AMPK activation. Therefore, GTP proves to be an effective natural agent for preventing NAFLD and reducing the risk of its severe complications such as nonalcoholic steatohepatitis, cirrhosis and hepatic cellular carcinoma.
Publish Date 2017-06-07 07:22
Citation Tan Y, Kim J, Cheng J, Ong M, Lao WG, Jin XL, Lin YG, Xiao L, Zhu XQ, Qu XQ. Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats. World J Gastroenterol 2017; 23(21): 3805-3814
URL http://www.wjgnet.com/1007-9327/full/v23/i21/3805.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i21.3805
Full Article (PDF) WJG-23-3805.pdf
Full Article (Word) WJG-23-3805.doc
Manuscript File 32796-Review.doc
Answering Reviewers 32796-Answering reviewers.pdf
Audio Core Tip 32796-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32796-Conflict-of-interest statement.pdf
Copyright License Agreement 32796-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 32796-Institutional animal care and use committee statement.pdf
Peer-review Report 32796-Peer-review(s).pdf
Scientific Misconduct Check 32796-Scientific misconduct check.pdf
Scientific Editor Work List 32796-Scientific editor work list.pdf