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Articles Published Processes
6/7/2017 7:22:42 AM | Browse: 1075 | Download: 1707
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Received |
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2017-01-25 19:42 |
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Peer-Review Started |
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2017-01-27 20:50 |
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To Make the First Decision |
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2017-03-03 10:08 |
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Return for Revision |
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2017-03-06 17:19 |
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Revised |
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2017-03-13 09:59 |
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Second Decision |
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2017-04-27 11:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-04 18:43 |
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Articles in Press |
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2017-05-04 18:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-25 08:48 |
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Publish the Manuscript Online |
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2017-06-07 07:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Lang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu and Xian-Qin Qu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xian-Qin Qu, PhD, MD, School of Medical and Molecular Biosciences, University of Technology Sydney, 15 Broadway, NSW 2007, Australia. xianqin.qu@uts.edu.au |
| Key Words |
Non-alcoholic fatty liver disease; Green tea polyphenols; Hepatic lipogenesis; Inflammatory cytokines; AMP-activated protein kinase |
| Core Tip |
The aim of this study was to examine the protective effects and molecular mechanism of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD)-induced by high fat diet (HFD) in genetically obese Zucker fatty (ZF) rats. The data of the study has demonstrated: (1) HFD-ZF rats is an optimal rodent model of NAFLD for testing novel/natural agents for this disease; (2) GTP treatment ameliorated metabolic and histopathological abnormalities in HFD-ZF rats with NAFLD; and (3) GTP exerted a protective effect against hepatic steatosis and liver injury by attenuating inflammatory cytokines and inhibiting lipogenesis through upregulating AMPK activation. Therefore, GTP proves to be an effective natural agent for preventing NAFLD and reducing the risk of its severe complications such as nonalcoholic steatohepatitis, cirrhosis and hepatic cellular carcinoma. |
| Publish Date |
2017-06-07 07:22 |
| Citation |
Tan Y, Kim J, Cheng J, Ong M, Lao WG, Jin XL, Lin YG, Xiao L, Zhu XQ, Qu XQ. Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats. World J Gastroenterol 2017; 23(21): 3805-3814 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i21/3805.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i21.3805 |
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