Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	32829
Country	Germany

Received	2017-01-26 21:32
Peer-Review Started	2017-01-26 22:18
To Make the First Decision	2017-04-17 09:27
Return for Revision	2017-05-02 21:05
Revised	2017-07-28 17:07
Second Decision	2017-08-11 07:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-16 17:51
Articles in Press	2017-08-16 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-02 07:47
Publish the Manuscript Online	2017-11-13 01:14

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Paneth cells in intestinal physiology and pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Nikolaus Gassler
Funding Agency and Grant Number
Corresponding Author	Nikolaus Gassler, MA, Professor, Institute of Pathology, RWTH Aachen University, Celler Strasse 38, Braunschweig 38114, Germany. ngassler@ukaachen.de
Key Words	Antimicrobial peptide; Paneth cell; Crohn’s disease; Microbiome; Small intestine
Core Tip	Paneth cells physiologically locate in small intestinal crypts. Wnt signalling promotes their differentiation and movement into crypts, whereas Notch activities antagonise Paneth cell maturation. The cells essentially contribute to crypt morphogenesis and intestinal homeostasis, sharpening the microbiome by secreting antimicrobial peptides, like defensins, and crypt fission. There is increasing molecular evidence that Paneth cells disorders are strongly involved in the pathophysiology of several intestinal diseases including ileal Crohn’s disease and necrotising enterocolitis.
Publish Date	2017-11-13 01:14
Citation	Gassler N. Paneth cells in intestinal physiology and patho¬physiology. World J Gastrointest Pathophysiol 2017; 8(4): 150-160
URL	http://www.wjgnet.com/2150-5330/full/v8/i4/150.htm
DOI	http://dx.doi.org/10.4291/wjgp.v8.i4.150

Full Article (PDF)	WJGP-8-150.pdf
Full Article (Word)	WJGP-8-150.doc
Manuscript File	32829-Review.doc
Answering Reviewers	32829-Answering reviewers.pdf
Audio Core Tip	32829-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32829-Conflict-of-interest statement.pdf
Copyright License Agreement	32829-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	32829-Language certificate.pdf
Peer-review Report	32829-Peer-review(s).pdf
Scientific Misconduct Check	32829-Scientific misconduct check.pdf
Scientific Editor Work List	32829-Scientific editor work list.pdf