Publication Name	World Journal of Gastroenterology
Manuscript ID	32847
Country	Japan

Received	2017-01-29 18:35
Peer-Review Started	2017-02-01 20:23
First Decision by Editorial Office Director
Return for Revision	2017-03-06 17:22
Revised	2017-03-14 12:12
Publication Fee Transferred
Second Decision by Editor	2017-05-04 17:39
Second Decision by Editor-in-Chief	2017-05-04 20:11
Final Decision by Editorial Office Director	2017-07-04 06:06
Articles in Press	2017-07-04 06:06
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-30 09:31
Publish the Manuscript Online	2017-08-07 09:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan
Manuscript Source	Invited Manuscript
All Author List	Tomiyasu Arisawa, Masakatsu Nakamura, Toshimi Otsuka, Wu Jing, Naoko Sakurai, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomomitsu Tahara and Tomoyuki Shibata
Funding Agency and Grant Number
Corresponding Author	Tomiyasu Arisawa, MD, PhD, Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan. tarisawa@kanazawa-med.ac.jp
Key Words	Maf protein K; Genetic polymorphism; Reactive oxygen species; Ulcerative colitis; Nuclear factor-erythroid 2-related factor 2
Core Tip	We investigated the association between maf protein K (MAFK), polymorphisms and ulcerative colitis in Japan. Both rs4268033 and rs3735656 minor allele homozygotes were significantly associated with the susceptibility to ulcerative colitis (UC) development. In addition, rs4268033 minor allele homozygote was significantly associated with all phenotypes of UC except the phenotype with younger age onset. Our results provided the first evidence that MAFK genetic polymorphisms were significantly associated with the susceptibility to UC development.
Publish Date	2017-08-07 09:17
Citation	Arisawa T, Nakamura M, Otsuka T, Jing W, Sakurai N, Takano H, Hayashi T, Ota M, Nomura T, Hayashi R, Shimasaki T, Tahara T, Shibata T. Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan. World J Gastroenterol 2017; 23(29): 5364-5370
URL	http://www.wjgnet.com/1007-9327/full/v23/i29/5364.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i29.5364

Full Article (PDF)	WJG-23-5364.pdf
Full Article (Word)	WJG-23-5364.doc