Publication Name	World Journal of Stem Cells
Manuscript ID	32866
Country	Sweden

Received	2017-02-07 13:47
Peer-Review Started	2017-02-08 16:49
To Make the First Decision	2017-04-17 09:27
Return for Revision	2017-04-17 14:10
Revised	2017-05-15 14:01
Second Decision	2017-07-06 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-17 06:07
Articles in Press	2017-07-17 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-18 07:55
Publish the Manuscript Online	2017-08-24 02:02

ISSN	1948-0210 (online)
Open Access
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Transplanting embryonic stem cells onto damaged human corneal endothelium
Manuscript Source	Invited Manuscript
All Author List	Charles Hanson, Arsaell Arnarsson, Thorir Hardarson, Ann Lindgård, Mandana Daneshvarnaeini, Catarina Ellerström, Anita Bruun and Ulf Stenevi
Funding Agency and Grant Number	Funding Agency Grant Number De Blindas Vänner, Gothenburg, and Greta Bergs Foundation, Lerum to Charles Hanson University of Akureyri Research Fund, the KEA Fund, and the Icelandic Council on Ageing to Arsaell Arnarsson Gothenburg Medical Society, the Medical Faculty of the University of Gothenburg and the Herman Svensson Foundation to Ulf Stenevi
Corresponding Author	Charles Hanson, PhD, Associate Professor of Reproductive Genetics, Unit of Reproductive Medicine, Sahlgrenska University Hospital, Blå stråket 6, Gothenburg 41345, Sweden. charles.hanson@obgyn.gu.se
Key Words	Embryonic stem cells; Cornea; Descemet’s membrane; Endothelium; Immunohistochemistry
Core Tip	This is the first report on the interaction between human embryonic stem cells (hESCs) and the inner parts of the human cornea. When hESCs were transplanted onto Descemet’s membrane (DM) in vitro we found that they were able to attach to and grow on DM in a single cell layer. Furthermore, the stem cells changed their morphology from small round cells to flat hexagonal cells. The transplanted hESCs also started to express the proteins paired box 6, Zona Occludens protein 1 and sodium potassium adenosine triphosphatase (NaKATPase), which also are expressed in human corneal endothelial cells.
Publish Date	2017-08-24 02:02
Citation	Hanson C, Arnarsson A, Hardarson T, Lindgård A, Daneshvarnaeini M, Ellerström C, Bruun A, Stenevi U. Transplanting embryonic stem cells onto damaged human corneal endothelium. World J Stem Cells 2017; 9(8): 127-132
URL	http://www.wjgnet.com/1948-0210/full/v9/i8/127.htm
DOI	http://dx.doi.org/10.4252/wjsc.v9.i8.127

Full Article (PDF)	WJSC-9-127.pdf
Full Article (Word)	WJSC-9-127.doc
Manuscript File	32866-Review.docx
Answering Reviewers	32866-Answering reviewers.pdf
Audio Core Tip	32866-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32866-Conflict-of-interest statement.pdf
Copyright License Agreement	32866-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32866-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	32866-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32866-Language certificate.pdf
Supplementary Material	32866_Letter to Editor.doc
Peer-review Report	32866-Peer-review(s).pdf
Scientific Misconduct Check	32886-Scientific misconduct check.pdf
Scientific Editor Work List	32866-Scientific editor work list.pdf