Publication Name	World Journal of Gastroenterology
Manuscript ID	32873
Country	Spain

Received	2017-01-30 12:18
Peer-Review Started	2017-02-01 15:38
To Make the First Decision	2017-02-23 10:27
Return for Revision	2017-02-27 15:24
Revised	2017-03-03 23:32
Second Decision	2017-04-11 17:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-04-12 18:17
Articles in Press	2017-04-12 18:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-24 16:07
Publish the Manuscript Online	2017-05-27 00:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives
Manuscript Source	Invited Manuscript
All Author List	Paloma Martín-Sanz, Marta Casado and Lisardo Boscá
Funding Agency and Grant Number	Funding Agency Grant Number MINECO SAF2014-52492R MINECO SAF2013-43713R, SAF2016-75004R ISCIII CIBERehd, CIBERcv FEDER FEDER
Corresponding Author	Lisardo Boscá, PhD, Department of Metabolism and Cell Signaling, Institute of Biomedical Research Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es
Key Words	Cyclooxygenase-2; NAS; Prostaglandin; Non-alcoholic steatohepatitis; Hepatocellular carcinoma
Core Tip	The assessment of the role of Cyclooxygenase-2 (COX-2) in hepatic diseases, ranging from non-alcoholic steatohepatitis to hepatocellular carcinoma, constitutes a field in which controversy exists probably because of the use of different experimental models. Since potent and selective inhibitors of COX-2 exist, but also stable PGE2 analogues to be used in therapy, unraveling the precise contribution of this enzyme and its products to the prevention of the progress of liver dysfunctions appears to be a useful approach for managing liver diseases.
Publish Date	2017-05-27 00:33
Citation	Martín-Sanz P, Casado M, Boscá L. Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives. World J Gastroenterol 2017; 23(20): 3572-3580
URL	http://www.wjgnet.com/1007-9327/full/v23/i20/3572.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i20.3572

Full Article (PDF)	WJG-23-3572.pdf
Full Article (Word)	WJG-23-3572.doc
Manuscript File	32873-Review.docx
Answering Reviewers	32873-Answering reviewers.pdf
Audio Core Tip	32873-Audio core tip.mp3
Copyright License Agreement	32873-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32873-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	32873-Language certificate.pdf
Peer-review Report	32873-Peer-review(s).pdf
Scientific Misconduct Check	32873-Scientific misconduct check.pdf
Scientific Editor Work List	32873-Scientific editor work list.pdf