Publication Name	World Journal of Orthopedics
Manuscript ID	32877
Country	Greece

Received	2017-01-30 12:26
Peer-Review Started	2017-02-03 10:23
First Decision by Editorial Office Director
Return for Revision	2017-03-09 14:56
Revised	2017-03-20 01:56
Publication Fee Transferred
Second Decision by Editor	2017-03-22 16:04
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-04-10 09:02
Articles in Press	2017-04-10 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-06 02:15
Publish the Manuscript Online	2017-06-16 08:41

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	Perioperative blood management strategies for patients undergoing total knee replacement: Where do we stand now?
Manuscript Source	Invited Manuscript
All Author List	Tzatzairis Themistoklis, Vogiatzaki Theodosia, Kazakos Konstantinos and Drosos I Georgios
Funding Agency and Grant Number
Corresponding Author	Drosos I Georgios, MD, PhD, Associate Professor of Orthopaedics, Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, St. Niarhos Street 1, Dragana, 68100 Alex¬androupolis, Greece. drosos@otenet.gr
Key Words	Total knee replacement; Transfusion; Total knee arthroplasty; Blood loss; Autologous blood donation; Blood management; Perioperative; Tranexamic acid; Tourniquet; Haemodilution; Anaemia; Transfusion protocol
Core Tip	Total knee replacement is one of the most common elective surgeries in orthopaedics. Blood loss during surgery is putting the patient at risk for a blood transfusion. A number of reviews and meta-analyses have tried to analyze the best blood conservation strategy. Our objective is to review any blood saving method/strategy into the preoperative, intraoperative and postoperative period and analyze their possible combination. A zero allogenic blood transfusion rate with safe and cost-effective methods should be the aim and an achievable goal.
Publish Date	2017-06-16 08:41
Citation	Themistoklis T, Theodosia V, Konstantinos K, Georgios DI. Perioperative blood management strategies for patients undergoing total knee replacement: Where do we stand now? World J Orthop 2017; 8(6): 441-454
URL	http://www.wjgnet.com/2218-5836/full/v8/i6/441.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i6.441

Full Article (PDF)	WJO-8-441.pdf
Full Article (Word)	WJO-8-441.doc
Manuscript File	32877-Review.docx
Answering Reviewers	32877-Answering reviewers.pdf
Audio Core Tip	32877-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32877-Conflict-of-interest statement.pdf
Copyright License Agreement	32877-Copyright assignment.pdf
Peer-review Report	32877-Peer-review(s).pdf
Scientific Misconduct Check	32877-Scientific misconduct check.pdf
Scientific Editor Work List	32877-Scientific editor work list.pdf