Publication Name	World Journal of Gastroenterology
Manuscript ID	32880
Country	Italy

Received	2017-01-30 12:40
Peer-Review Started	2017-02-01 20:48
To Make the First Decision	2017-03-03 10:08
Return for Revision	2017-03-06 17:23
Revised	2017-03-14 04:57
Second Decision	2017-04-11 17:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-12 18:17
Articles in Press	2017-04-12 18:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-28 09:37
Publish the Manuscript Online	2017-05-06 20:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Esophagitis and its causes: Who is “guilty” when acid is found “not guilty”?
Manuscript Source	Invited Manuscript
All Author List	Laurino Grossi, Antonio Francesco Ciccaglione and Leonardo Marzio
Funding Agency and Grant Number
Corresponding Author	Laurino Grossi, MD, Associate Professor, Gastroenterology, G. d’Annunzio University Chieti-Pescara, School of Gastroenterology c/o Digestive Sciences - Ospedale Spirito Santo, Via Fonte Romana, 8 65124 Pescara, Italy. l.grossi@unich.it
Key Words	Esophagitis; Gastroesophageal reflux disease; Eosinophilic esophagitis; Crohn’s disease; Herpes simplex virus; Manometry; Candida; Caustic; Dysphagia; Chest pain
Core Tip	This manuscript analyzes the esophageal diseases whose etiology is not directly related to abnormal gastro-esophageal reflux episodes. These conditions occur less frequently than gastroesophageal reflux disease, but their diagnosis should always be considered when managing patients with unexplained upper gastrointestinal symptoms. Some of these diseases are immune-mediated inflammatory pro­cesses, either limited to the esophageal wall such as Eosinophilic esophagitis or part of systemic diseases such as Crohn’s disease. Other possible etiologies include viral or fungal infections in immunocompromised patients, and corrosive agents causing direct damage to the esophageal mucosa as well as therapeutic regimen used for neoplasms. All these possibilities should be taken into consideration when Reflux esophagitis cannot be diagnosed.
Publish Date	2017-05-06 20:30
Citation	Grossi L, Ciccaglione AF, Marzio L. Esophagitis and its causes: Who is “guilty” when acid is found “not guilty”? World J Gastroenterol 2017; 23(17): 3011-3016
URL	http://www.wjgnet.com/1007-9327/full/v23/i17/3011.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i17.3011

Full Article (PDF)	WJG-23-3011.pdf
Full Article (Word)	WJG-23-3011.doc
Manuscript File	32880-Review.doc
Answering Reviewers	32880-Answering reviewers.pdf
Audio Core Tip	32880-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	32880-Conflict-of-interest statement.pdf
Copyright License Agreement	32880-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	32880-Language certificate.pdf
Supplementary Material	Supplementary_Material_20170125055040.doc
Peer-review Report	32880-Peer-review(s).pdf
Scientific Misconduct Check	32880-Scientific misconduct check.pdf
Scientific Editor Work List	32880-Scientific editor work list.pdf