Publication Name	World Journal of Gastroenterology
Manuscript ID	32886
Country	Sweden

Received	2017-01-30 12:57
Peer-Review Started	2017-02-01 00:21
To Make the First Decision	2017-04-05 17:18
Return for Revision	2017-04-05 18:57
Revised	2017-04-26 19:45
Second Decision	2017-06-16 12:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-19 08:40
Articles in Press	2017-06-19 08:40
Publication Fee Transferred	2017-07-07 02:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-15 12:00
Publish the Manuscript Online	2017-08-28 06:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies
Manuscript Source	Unsolicited Manuscript
All Author List	Per Hedenström, Bengt Nilsson, Akif Demir, Carola Andersson, Fredrik Enlund, Ola Nilsson and Riadh Sadik
Funding Agency and Grant Number	Funding Agency Grant Number The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-564381 The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-665681 The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-373551 Sahlgrenska University Hospital LUA-ALF 73830 The Swedish Society of Medicine SLS-404261 The Swedish Society of Medicine SLS-325061
Corresponding Author	Dr. Riadh Sadik, Associate Professor, Division of Medical Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 3, S-413 45 Gothenburg, Sweden. riadh.sadik@vgregion.se
Key Words	Endosonography; Fine-needle biopsy; Gastrointestinal stromal tumor; KIT; Platelet-derived growth factor alpha; Tumor proliferation rate; Ki-67 index; Neoadjuvant treatment; Imatinib
Core Tip	Personalization of the management and treatment of gastrointestinal stromal tumors (GIST) requires an extensive characterization of individual tumors. Information on the tumor proliferation rate and the KIT- and platelet-derived growth factor alpha (PDGFRA)-mutation profile is essential. While endoscopic ultrasound (EUS)-FNA is reported to be suboptimal for the diagnosis of GIST, EUS-guided biopsy sampling (EUS-FNB) has not been evaluated for the characterization of GISTs. This prospective, long-term study showed that EUS-FNB was safe and highly accurate for the pretreatment diagnosis of GISTs, for the sequencing of KIT and PDGFRA, and for the assessment of the tumor proliferation rate (Ki-67-index). By obtaining this information, we managed to guide and evaluate neoadjuvant imatinib therapy in patients with GIST.
Publish Date	2017-08-28 06:54
Citation	Hedenström P, Nilsson B, Demir A, Andersson C, Enlund F, Nilsson O, Sadik R. Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies. World J Gastroenterol 2017; 23(32): 5925-5935
URL	http://www.wjgnet.com/1007-9327/full/v23/i32/5925.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i32.5925

Full Article (PDF)	WJG-23-5925.pdf
Full Article (Word)	WJG-23-5925.doc
Manuscript File	32886-Review.docx
Answering Reviewers	32886-Answering reviewers.pdf
Audio Core Tip	32886-Audio core tip.mp3
Biostatistics Review Certificate	32886-Biostatistics statement.pdf
Clinical Trial Registration Statement	32886-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	32886-Conflict-of-interest statement.pdf
Copyright License Agreement	32886-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32886-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	32886-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	32886-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32886-Language certificate.pdf
Supplementary Material	32886-Supplementary material.pdf
Peer-review Report	32886-Peer-review(s).pdf
Scientific Misconduct Check	32886-Scientific misconduct check.pdf
Scientific Editor Work List	32886-Scientific editor work list.pdf