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Articles Published Processes
8/28/2017 6:54:48 AM | Browse: 1396 | Download: 3373
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Received |
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2017-01-30 12:57 |
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Peer-Review Started |
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2017-02-01 00:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2017-04-05 18:57 |
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Revised |
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2017-04-26 19:45 |
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Publication Fee Transferred |
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2017-07-07 02:21 |
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Second Decision by Editor |
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2017-06-16 12:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-06-19 08:40 |
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Articles in Press |
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2017-06-19 08:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-15 12:00 |
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Publish the Manuscript Online |
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2017-08-28 06:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Per Hedenström, Bengt Nilsson, Akif Demir, Carola Andersson, Fredrik Enlund, Ola Nilsson and Riadh Sadik |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland |
VGFOUREG-564381 |
| The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland |
VGFOUREG-665681 |
| The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland |
VGFOUREG-373551 |
| Sahlgrenska University Hospital |
LUA-ALF 73830 |
| The Swedish Society of Medicine |
SLS-404261 |
| The Swedish Society of Medicine |
SLS-325061 |
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| Corresponding Author |
Dr. Riadh Sadik, Associate Professor, Division of Medical Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 3, S-413 45 Gothenburg, Sweden. riadh.sadik@vgregion.se |
| Key Words |
Endosonography; Fine-needle biopsy; Gastrointestinal stromal tumor; KIT; Platelet-derived growth factor alpha; Tumor proliferation rate; Ki-67 index; Neoadjuvant treatment; Imatinib |
| Core Tip |
Personalization of the management and treatment of gastrointestinal stromal tumors (GIST) requires an extensive characterization of individual tumors. Information on the tumor proliferation rate and the KIT- and platelet-derived growth factor alpha (PDGFRA)-mutation profile is essential. While endoscopic ultrasound (EUS)-FNA is reported to be suboptimal for the diagnosis of GIST, EUS-guided biopsy sampling (EUS-FNB) has not been evaluated for the characterization of GISTs. This prospective, long-term study showed that EUS-FNB was safe and highly accurate for the pretreatment diagnosis of GISTs, for the sequencing of KIT and PDGFRA, and for the assessment of the tumor proliferation rate (Ki-67-index). By obtaining this information, we managed to guide and evaluate neoadjuvant imatinib therapy in patients with GIST. |
| Publish Date |
2017-08-28 06:54 |
| Citation |
Hedenström P, Nilsson B, Demir A, Andersson C, Enlund F, Nilsson O, Sadik R. Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies. World J Gastroenterol 2017; 23(32): 5925-5935 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i32/5925.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i32.5925 |
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