| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Ming Liu, Can-Xia Xu, Lin-Fang Zhang, Li-Hua Huang, Ting-Zi Hu, Rong Li, Xiu-Juan Xia, Lin-Yong Xu, Ling Luo, Xiao-Xia Jiang and Ming Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| New Xiangya Talent Project of the Third Xiangya Hospital of Central South University |
20150310 |
|
| Corresponding Author |
Can-Xia Xu, MD, Department of Gastroenterology, the Third Xiangya Hospital of Central South University, No. 138 Tongzipo Street, Changsha 410013, Hunan Province, China. xucanxia2000@163.com |
| Key Words |
Helicobacter pylori; Inflammation-carcinoma chain; Connexin 32; PBX1; Carcinogenesis |
| Core Tip |
In this paper, we first report on the increasing tendency of transcriptional factor PBX1 in response to Helicobacter pylori (H. pylori) infection. This is significant because H. pylori is the predominant factor of gastric carcinoma, and the enhanced PBX1 expression in epithelial cells was first revealed as a marker of H. pylori-associated gastric carcinogenesis. Moreover, PBX1 transcriptionally downregulates the expression of connexin 32, which is vital to epithelial cell-cell communication, indicating an anti-cancer target that prevents the accumulation of PBX1 in the presence of H. pylori infection. |
| Publish Date |
2017-08-07 09:17 |
| Citation |
Liu XM, Xu CX, Zhang LF, Huang LH, Hu TZ, Li R, Xia XJ, Xu LY, Luo L, Jiang XX, Li M. PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis. World J Gastroenterol 2017; 23(29): 5345-5355 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i29/5345.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i29.5345 |
