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Articles Published Processes
6/26/2017 10:23:06 AM | Browse: 1216 | Download: 1963
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Received |
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2017-02-01 12:45 |
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Peer-Review Started |
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2017-02-02 13:45 |
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To Make the First Decision |
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2017-03-16 13:18 |
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Return for Revision |
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2017-03-20 16:51 |
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Revised |
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2017-03-27 20:53 |
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Second Decision |
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2017-05-18 03:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-19 07:59 |
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Articles in Press |
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2017-05-19 07:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-06-21 02:46 |
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Publish the Manuscript Online |
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2017-06-26 10:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Viera Tischlerova, Martin Kello, Mariana Budovska and Jan Mojzis |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants of the Slovak Grant Agency for Science |
VEGA 1/0322/14 |
| Grants of the Slovak Grant Agency for Science |
VEGA 1/0753/17 |
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| Corresponding Author |
Jan Mojzis, Professor, DVM, DSc, Department of Pharmacology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovak Republic. jan.mojzis@upjs.sk |
| Key Words |
Colorectal carcinoma; Indole phytoalexins; Antiproliferative; Apoptosis; Intrinsic pathway |
| Core Tip |
In this study we inform about our first results obtained from cell proliferation assays, flow cytometry analysis and Western blot analysis of HCT116 cells after treatment with compound K-453, which belongs to a group of synthetic derivatives of indole phytoalexins originally isolated from cruciferous vegetables. This study demonstrates that our compound induces the mitochondrial pathway of apoptosis and that the antiproliferative effect of our substance may be linked to inhibition of several signaling pathways. Our results provide a rationale for further in vivo anticancer efficacy studies. |
| Publish Date |
2017-06-26 10:23 |
| Citation |
Tischlerova V, Kello M, Budovska M, Mojzis J. Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. World J Gastroenterol 2017; 23(24): 4341-4353 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i24/4341.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i24.4341 |
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