Publication Name	World Journal of Gastroenterology
Manuscript ID	32974
Country	China

Received	2017-02-03 16:06
Peer-Review Started	2017-02-04 08:13
First Decision by Editorial Office Director
Return for Revision	2017-04-27 10:16
Revised	2017-06-19 13:43
Publication Fee Transferred	2017-07-27 08:16
Second Decision by Editor	2017-07-21 07:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-07-24 07:58
Articles in Press	2017-07-24 07:58
Edit the Manuscript by Language Editor	2017-08-04 21:15
Typeset the Manuscript	2017-08-24 12:49
Publish the Manuscript Online	2017-08-28 06:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Rui Xie, Jun-Yan An, Li-Bo Zheng, Xiao-Xia Huo, Jian Guo, David Shih and Xiao-Lan Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30872513
Corresponding Author	Xiao-Lan Zhang, MD, PhD, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, 215 West Heping Road, Shijiazhuang 050000, Hebei Province, China. xiaolanzh@hb2h.com
Key Words	Collagen metabolism; hepatic stellate cells; Phosphatase and tension homologue deleted on chromosome ten; PTEN; Gene therapy; Hepatic fibrosis
Core Tip	Phosphatase and tension homologue deleted on chromosome ten (PTEN) has a negative relation with the activation and proliferation of hepatic stellate cells (HSCs), which is the central event in liver fibrogenesis as HSCs are the major source of collagens and matrix metalloproteinases in fibrotic liver. In this study, adenoviruses containing cDNA constructs encoding wild-type PTEN (Ad-PTEN) and PTEN mutant G129E gene (Ad-G129E) were constructed to over-express the PTEN gene in both rat primary HSCs and human LX-2 cells as well as in the CCl4-induced rat liver fibrosis model. The adenovirus-mediated over-expression of the PTEN gene attenuated extracellular matrix (ECM) synthesis (collagens Ⅰ and Ⅲ) and promoted ECM degradation, representing a possible novel anti-fibrosis therapy.
Publish Date	2017-08-28 06:54
Citation	Xie SR, An JY, Zheng LB, Huo XX, Guo J, Shih D, Zhang XL. Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis. World J Gastroenterol 2017; 23(32): 5904-5912
URL	http://www.wjgnet.com/1007-9327/full/v23/i32/5904.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i32.5904

Full Article (PDF)	WJG-23-5904.pdf
Full Article (Word)	WJG-23-5904.doc