Publication Name	World Journal of Gastroenterology
Manuscript ID	33005
Country	Greece

Received	2017-02-03 20:00
Peer-Review Started	2017-02-04 08:06
To Make the First Decision	2017-02-23 10:28
Return for Revision	2017-02-27 15:19
Revised	2017-03-28 01:25
Second Decision	2017-05-04 17:40
Accepted by Journal Editor-in-Chief	2017-05-05 03:27
Accepted by Executive Editor-in-Chief	2017-05-09 17:10
Articles in Press	2017-05-09 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-16 07:15
Publish the Manuscript Online	2017-06-26 10:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and was fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Risk of hepatitis B reactivation in patients treated with direct-acting antivirals for hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Ioanna Aggeletopoulou, Christos Konstantakis, Spilios Manolakopoulos and Christos Triantos
Funding Agency and Grant Number
Corresponding Author	Christos Triantos, MD, Department of Gastroenterology, University Hospital of Patras, D. Stamatopoulou 4, Rio 26504, Patras, Greece. chtriantos@hotmail.com
Key Words	Hepatitis B; Hepatitis C; Hepatitis B virus reactivation; Direct-acting antivirals; Pretreatment screening
Core Tip	Hepatitis B reactivation is related to an abrupt increase in hepatitis B virus (HBV) replication in patients with inactive or resolved hepatitis B. Most cases of HBV reactivation resolve spontaneously, but the existence of continuous immune suppression leads to hepatitis flare development and then to progressive acute hepatic injury. The introduction of direct-acting antiviral drugs (DAAs) treatment increases the risk of HBV reactivation in hepatitis C virus (HCV) /HBV co-infected patients. The high incidence of HBV reactivation in these patients highlights the necessity for HBV pretreatment screening before initiation and during DAA therapy.
Publish Date	2017-06-26 10:23
Citation	Aggeletopoulou I, Konstantakis C, Manolakopoulos S, Triantos C. Risk of hepatitis B reactivation in patients treated with direct-acting antivirals for hepatitis C. World J Gastroenterol 2017; 23(24): 4317-4323
URL	http://www.wjgnet.com/1007-9327/full/v23/i24/4317.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i24.4317

Full Article (PDF)	WJG-23-4317.pdf
Full Article (Word)	WJG-23-4317.doc
Manuscript File	33005-Review.docx
Answering Reviewers	33005-Answering reviewers.pdf
Audio Core Tip	33005-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33005-Conflict-of-interest statement.pdf
Copyright License Agreement	33005-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33005-Language certificate.pdf
Peer-review Report	33005-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33005-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33005-Scientific misconduct check.pdf
Scientific Editor Work List	33005-Scientific editor work list.pdf