Publication Name	World Journal of Gastroenterology
Manuscript ID	3301
Country	China

Received	2013-04-21 21:00
Peer-Review Started	2013-04-22 13:55
To Make the First Decision	2013-05-14 18:44
Return for Revision	2013-05-17 15:14
Revised	2013-06-05 23:05
Second Decision	2013-07-18 17:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 02:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-07 17:06
Publish the Manuscript Online	2013-08-19 18:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways
Manuscript Source	Invited Manuscript
All Author List	Xuan Huang, Bin Lv, Shuo Zhang, Qun Dai, Bing-Bing Chen and Li-Na Meng
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province of China LY12H29002 Scientific Research from Chinese Herbal Drug Administration 2011ZB032
Corresponding Author	Bin Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Youdian Road 54, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn
Key Words	Radix curcumae-derived diterpenoid C; Helicobacter pylori; Nuclear factor-κB; Inflammatory cytokine
Core Tip	Radix curcumae (RC), a common Chinese crude drug, has a wide range of pharmacological activity including hypolipidemic effect, hepatoprotective effect, anti-tumor, anti-radiation and anti-anaphylaxis. RC-derived diterpenoid C is recently obtained from RC ether extract by us, and its chemical properties and constitution are different from curcumin and 飦?elemene. Our results showed that RC-derived diterpenoid C can block nuclear factor kappa B signal pathway, effectively reducing the secretion of Helicobacter pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine. RC-derived diterpenoid C may become an effective drug for treatment of chronic gastritis.
Publish Date	2013-08-19 18:22
Citation	Huang X, Lv B, Zhang S, Dai Q, Chen BB, Meng LN. Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways. World J Gastroenterol 2013; 19(31): 5085-5093
URL	http://www.wjgnet.com/1007-9327/full/v19/i31/5085.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i31.5085

Full Article (PDF)	WJG-19-5085.pdf
Manuscript File	3301-Review.doc
Answering Reviewers	3301-Answering reviewers.pdf
Copyright License Agreement	3301-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3301-Language certificate.pdf
Peer-review Report	3301-Peer reviews.pdf
Scientific Editor Work List	3301-Scientific editor work list.doc