| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C
|
| Manuscript Source |
Invited Conference Manuscripts |
| All Author List |
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska and Danuta Januszkiewicz-Lewandowska |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Danuta Januszkiewicz-Lewandowska, MD, PhD, Professor, Department of Pediatric Oncology, Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland. danuta.januszkiewicz@ump.edu.pl |
| Key Words |
Hepatitis C virus; Chronic hepatitis C; Interferon lambda 3; Interleukin 28B; rs4803217 |
| Core Tip |
The rs4803217 single nucleotide polymorphism of IFNL3 (IL28B) gene, which encodes, interferon lambda 3 (interleukin 28B), has been proposed as a causal variant that may influence hepatitis C virus (HCV) clearance. In the present study it was found that rs4803217 is a strong and independent predictor of sustained virological response and relapse in HCV genotype 1 infected chronic hepatitis C patients treated with pegylated interferon alpha and ribavirin. Moreover, it was indicated that rs4803217 seems to be much better predictor of therapy outcome than well-establish IFNL3 SNPs (rs12979860, rs8099917 and rs12980275). |
| Publish Date |
2017-06-07 07:22 |
| Citation |
Świątek-Kościelna B, Kałużna E, Strauss E, Nowak J, Bereszyńska I, Gowin E, Wysocki J, Rembowska J, Barcińska D, Mozer-Lisewska I, Januszkiewicz-Lewandowska D. Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C. World J Gastroenterol 2017; 23(21): 3815-3824 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i21/3815.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i21.3815 |
