Publication Name	World Journal of Gastroenterology
Manuscript ID	33075
Country	Italy

Received	2017-02-04 15:03
Peer-Review Started	2017-02-05 22:19
To Make the First Decision	2017-04-26 08:28
Return for Revision	2017-04-27 09:45
Revised	2017-05-03 22:43
Second Decision	2017-06-12 05:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-06-19 09:06
Articles in Press	2017-06-19 09:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-27 03:17
Publish the Manuscript Online	2017-07-07 11:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract
Manuscript Source	Invited Manuscript
All Author List	Andrea Ferrigno, Clarissa Berardo, Laura G Di Pasqua, Veronica Siciliano, Plinio Richelmi and Mariapia Vairetti
Funding Agency and Grant Number	Funding Agency Grant Number Italian ministry of University, Research and Instruction
Corresponding Author	Andrea Ferrigno, PhD, Department of Internal Medicine and Therapeutics (Cellular and Molecular Pharmacology and Toxicology), University of Pavia, Strada Nuova 65, Pavia 27100, Italy. andrea.ferrigno@unipv.it
Key Words	Metabotropic glutamate receptor subtype 5; Esophagus; Intestine; Liver; Pancreas
Core Tip	Metabotropic glutamate 5 receptors (mGluR5s) belong to Group I mGlu receptors which are coupled to the inositol trisphosphate/diacylglycerol pathway. As well as in the brain, mGluR5s and their ligands have been found in peripheral organs, including those associated with the gastrointestinal (GI) tract. We review published findings about their identification and role in the mouth, esophagus, stomach and intestine and accessory digestive organs such as the tongue, liver and pancreas. We conclude that mGluR5s are still poorly studied in the GI tract and their peripheral non-synaptic signaling, and that their therapeutic potential needs to be further investigated.
Publish Date	2017-07-07 11:41
Citation	Ferrigno A, Berardo C, Di Pasqua LG, Siciliano V, Richelmi P, Vairetti M. Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract. World J Gastroenterol 2017; 23(25): 4500-4507
URL	http://www.wjgnet.com/1007-9327/full/v23/i25/4500.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i25.4500

Full Article (PDF)	WJG-23-4500.pdf
Full Article (Word)	WJG-23-4500.doc
Manuscript File	33075-Review.docx
Answering Reviewers	33075-Answering reviewers.pdf
Audio Core Tip	33075-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33075-Conflict-of-interest statement.pdf
Copyright License Agreement	33075-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33075-Language certificate.pdf
Peer-review Report	33075-Peer-review(s).pdf
Scientific Misconduct Check	33075-Scientific misconduct check.pdf
Scientific Editor Work List	33075-Scientific editor work list.pdf