Publication Name	World Journal of Virology
Manuscript ID	33083
Country	United States

Received	2017-02-06 16:56
Peer-Review Started	2017-02-07 10:35
To Make the First Decision	2017-03-08 09:41
Return for Revision	2017-03-10 17:07
Revised	2017-04-28 02:43
Second Decision	2017-05-24 01:05
Accepted by Journal Editor-in-Chief	2017-05-25 06:16
Accepted by Executive Editor-in-Chief	2017-06-07 07:21
Articles in Press	2017-06-07 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-08 09:17
Publish the Manuscript Online	2017-08-09 04:13

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Basic Study
Article Title	Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes
Manuscript Source	Invited Manuscript
All Author List	Eyone Jones, Pavel Mazirka, Margaret A McNurlan, Frank Darras, Marie C Gelato and Giuseppe Caso
Funding Agency and Grant Number
Corresponding Author	Giuseppe Caso, MD, PhD, Department of Surgery, Stony Brook University Medical Center, 100 Nicolls Rd, Stony Brook, NY 11794, United States. giuseppe.caso@stonybrook.edu
Key Words	Nucleoside reverse transcriptase inhibitors; Non-nucleoside reverse transcriptase inhibitors; Protease inhibitors; Pre-adipocytes; Highly active antiretroviral therapy; Lipodystrophy
Core Tip	We demonstrated an in vitro system for evaluating potential antiretroviral regimens for adipose tissue toxicity. In general, combination regimens resulted in greater preadipocyte proliferation and differentiation inhibition than single therapies. The drug combination of atazanavir + emtricitabine + tenofovir had inhibitory effects on preadipocytes and adding ritonavir at levels equivalent to clinical boosting, increased toxicity still further.
Publish Date	2017-08-09 04:13
Citation	Jones E, Mazirka P, McNurlan MA, Darras F, Gelato MC, Caso G. Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes. World J Virol 2017; 6(3): 53-58
URL	http://www.wjgnet.com/2220-3249/full/v6/i3/53.htm
DOI	http://dx.doi.org/10.5501/wjv.v6.i3.53

Full Article (PDF)	WJV-6-53.pdf
Full Article (Word)	WJV-6-53.doc
Manuscript File	33083-Review.docx
Answering Reviewers	33083-Answering reviewers.pdf
Audio Core Tip	33083-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33083-Conflict-of-interest statement.pdf
Copyright License Agreement	33083-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20170128013940.docx
Institutional Review Board Approval Form or Document	33083-Institutional review board statement.pdf
Peer-review Report	33083-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33083-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33083-Scientific misconduct check.pdf
Scientific Editor Work List	33083-Scientific editor work list.pdf