Publication Name	World Journal of Cardiology
Manuscript ID	33097
Country	Canada

Received	2017-02-06 15:02
Peer-Review Started	2017-02-10 16:07
To Make the First Decision	2017-03-06 18:09
Return for Revision	2017-03-07 14:51
Revised	2017-03-22 04:59
Second Decision	2017-04-14 11:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-24 10:06
Articles in Press	2017-04-24 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-16 12:18
Publish the Manuscript Online	2017-06-26 00:49

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Influence of cardiac nerve status on cardiovascular regulation and cardioprotection
Manuscript Source	Invited Manuscript
All Author List	John G Kingma, Denys Simard and Jacques R Rouleau
Funding Agency and Grant Number
Corresponding Author	John G Kingma, PhD, Department of Medicine, Faculty of Medicine, Laval University, 2725 chemin Ste-Foy, Ste-Foy, Québec, QC G1V 4G5, Canada. john.kingma@fmed.ulaval.ca
Key Words	Intrinsic cardiac nervous system; Myocardial ischemia; Ischemic conditioning; Autonomic neuropathy; Coronary blood flow regulation
Core Tip	Neural elements within the intrinsic cardiac nervous system are known to transduce sensory inputs from the heart, blood vessels and surrounding organs to ensure beat-to-beat regulation of cardiac function. Development of autonomic neurophathies in patients with comorbidities compromises clinical outcomes. Myocardial ischemia also significantly affects cardiocytes as well as cardiac neurons; post-ischemic remodelling might affect neuronal function and thereby contribute to cardiac instability. Different protection strategies including ischemic conditioning and neuromodulation interventions that limit neural injury and help main­tain cardiovascular function are the subject of ongoing investigations.
Publish Date	2017-06-26 00:49
Citation	Kingma JG, Simard D, Rouleau JR. Influence of cardiac nerve status on cardiovascular regulation and cardioprotection. World J Cardiol 2017; 9(6): 508-520
URL	http://www.wjgnet.com/1949-8462/full/v9/i6/508.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i6.508

Full Article (PDF)	WJC-9-508.pdf
Full Article (Word)	WJC-9-508.doc
Manuscript File	33097-Review.docx
Answering Reviewers	33097-Answering reviewers.pdf
Audio Core Tip	33097-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33097-Conflict-of-interest statement.pdf
Copyright License Agreement	33097-Copyright assignment.pdf
Peer-review Report	33097-Peer-review(s).pdf
Scientific Misconduct Check	33097-Scientific misconduct check.pdf
Scientific Editor Work List	33097-Scientific editor work list.pdf