Publication Name	World Journal of Gastroenterology
Manuscript ID	33099
Country	Italy

Received	2017-02-06 14:58
Peer-Review Started	2017-02-09 08:36
To Make the First Decision	2017-02-23 09:31
Return for Revision	2017-02-23 16:09
Revised	2017-03-12 06:06
Second Decision	2017-04-11 18:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-04-12 18:47
Articles in Press	2017-04-12 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-24 14:59
Publish the Manuscript Online	2017-05-15 06:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Liver transplantation for intermediate hepatocellular carcinoma: An adaptive approach
Manuscript Source	Invited Manuscript
All Author List	Marco Biolato, Giuseppe Marrone, Luca Miele, Antonio Gasbarrini and Antonio Grieco
Funding Agency and Grant Number
Corresponding Author	Antonio Grieco, MD, Professor, Liver Transplant Medicine, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, Fondazione Policlinico Universitario Gemelli, Universita’ Cattolica del Sacro Cuore, Largo A. Gemelli 8, 00168 Roma, Italy. antonio.grieco@unicatt.it
Key Words	Milan criteria; α-fetoprotein; Down-staging; Allocation; Adaptive approach
Core Tip	Hepatocellular carcinoma is an increasing indication for liver transplantation, but the selection of patients is challenging because of organ shortages. Conventional Milan criteria is the reference for the selection of patients worldwide, but many expanded criteria have also demonstrated satisfactory results. Correct staging should include surrogate markers of biological aggressiveness. Additionally, successful down-staging can help select patients with a more favorable biology. Allocation rules are adjusted to minimize the imbalance between the priorities of candidates with and without hepatocellular carcinoma. Recently, a benefit-oriented “adaptive approach” was proposed, in which the selection and allocation of patients are based on their response to treatments.
Publish Date	2017-05-15 06:16
Citation	Biolato M, Marrone G, Miele L, Gasbarrini A, Grieco A. Liver transplantation for intermediate hepatocellular carcinoma: An adaptive approach. World J Gastroenterol 2017; 23(18): 3195-3204
URL	http://www.wjgnet.com/1007-9327/full/v23/i18/3195.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i18.3195

Full Article (PDF)	WJG-23-3195.pdf
Full Article (Word)	WJG-23-3195.doc
Manuscript File	33099-Review.docx
Answering Reviewers	33099-Answering reviewers.pdf
Audio Core Tip	33099-Audio core tip.wma
Conflict-of-Interest Disclosure Form	33099-Conflict-of-interest statement.pdf
Copyright License Agreement	33099-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33099-Language certificate.pdf
Peer-review Report	33099-Peer-review(s).pdf
Scientific Misconduct Check	33099-Scientific misconduct check.pdf
Scientific Editor Work List	33099-Scientific editor work list.pdf