Publication Name	World Journal of Gastroenterology
Manuscript ID	33121
Country	Brazil

Received	2017-02-06 14:55
Peer-Review Started	2017-02-08 17:31
To Make the First Decision	2017-03-03 09:15
Return for Revision	2017-03-03 11:15
Revised	2017-04-06 10:07
Second Decision	2017-06-16 12:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-19 08:40
Articles in Press	2017-06-19 08:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-07-14 12:37
Publish the Manuscript Online	2017-07-20 10:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Camila Ribeiro de Avelar, Emile Miranda Pereira, Priscila Ribas de Farias Costa, Rosângela Passos de Jesus and Lucivalda Pereira Magalhães de Oliveira
Funding Agency and Grant Number
Corresponding Author	Camila Ribeiro de Avelar, MD, Post-graduation Program, Federal University of Bahia, 32 Araújo Pinho Street, Canela, Salvador, Bahia 40.110-150, Brazil. contato@camilaavelar.com.br
Key Words	Systematic review; liver diseases; Milk thistle; Silymarin; Meta-analysis
Core Tip	Silymarin is commonly prescribed in the practice of many professionals and ingested as self-medication for patients. Studies suggest benefits of its use in hepatic disorders, discussing its mechanisms of action and potential as a coadjutant in the treatment of those diseases. Favorable clinical outcomes as improvement of biochemical indicators and liver profile were observed in clinical trials. However, other studies are controversial or have not reported statistical significance in the improvement of these indicators. Facing the differences and methodological peculiarities of these studies, a systematic review with meta-analysis was performed to clarify the real benefits of silymarin in liver diseases.
Publish Date	2017-07-20 10:12
Citation	de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. World J Gastroenterol 2017; 23(27): 5004-5017
URL	http://www.wjgnet.com/1007-9327/full/v23/i27/5004.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i27.5004

Full Article (PDF)	WJG-23-5004.pdf
Full Article (Word)	WJG-23-5004.doc
Manuscript File	33121-Review.docx
Answering Reviewers	33121-Answering reviewers.pdf
Audio Core Tip	33121-Audio core tip.mp3
Biostatistics Review Certificate	33121-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33121-Conflict-of-interest statement.pdf
Copyright License Agreement	33121-Copyright assignment.pdf
Peer-review Report	33121-Peer-review(s).pdf
Scientific Misconduct Check	33121-Scientific misconduct check.pdf
Scientific Editor Work List	33121-Scientific editor work list.pdf