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Articles Published Processes
5/20/2017 12:26:24 PM | Browse: 1113 | Download: 1694
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Received |
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2017-02-07 17:24 |
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Peer-Review Started |
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2017-02-08 13:48 |
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To Make the First Decision |
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2017-03-03 10:06 |
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Return for Revision |
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2017-03-07 10:37 |
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Revised |
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2017-03-17 01:45 |
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Second Decision |
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2017-04-11 17:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-04-12 18:24 |
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Articles in Press |
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2017-04-12 18:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-08 16:32 |
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Publish the Manuscript Online |
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2017-05-20 12:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Renin angiotensin system in liver diseases: Friend or foe?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Cristina Simões e Silva, Aline S MIranda, Natália P Rocha and Antônio L Teixeira |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CNPq |
460334/2014-0 |
| FAPEMIG |
00555-15 |
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| Corresponding Author |
Ana Cristina Simões e Silva, MD, PhD, Professor, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, UFMG, Alfredo Balena Avenue, Number 190, 2nd floor, Room 281, Belo Horizonte, MG 30130-100, Brazil. acssilva@hotmail.com |
| Key Words |
Renin angiotensin system; Angiotensin Ⅱ; Angiotensin-(1-7); Hepatic cirrhosis; Liver fibrosis; Hepatorenal syndrome |
| Core Tip |
This Editorial reports recent advances on the understanding of the renin angiotensin system in regard to the role of the two main and counter-regulatory mediators, Angiotensin Ⅱ and Angiotensin-(1-7), in liver diseases and in their main complications. Experimental and clinical findings so far show that Angiotensin-(1-7) by binding to Mas receptor opposes Angiotensin Ⅱ actions mediated by AT1 receptors in liver tissue, by eliciting anti-inflammatory, anti-oxidative and anti-fibrotic effects. This knowledge may help in paving the way for the development of novel treatments for liver diseases and their complications. |
| Publish Date |
2017-05-20 12:26 |
| Citation |
Simões e Silva AC, Miranda AS, Rocha NP, Teixeira AL. Renin angiotensin system in liver diseases: Friend or foe? World J Gastroenterol 2017; 23(19): 3396-3406 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i19/3396.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i19.3396 |
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