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Articles Published Processes
7/12/2017 6:45:23 AM | Browse: 1031 | Download: 1595
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Received |
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2017-02-08 16:05 |
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Peer-Review Started |
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2017-02-10 10:53 |
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To Make the First Decision |
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2017-03-03 10:05 |
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Return for Revision |
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2017-03-07 10:40 |
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Revised |
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2017-04-07 07:07 |
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Second Decision |
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2017-05-18 03:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-19 07:59 |
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Articles in Press |
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2017-05-19 07:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-01 06:58 |
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Publish the Manuscript Online |
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2017-07-12 06:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dorota Cibor, Danuta Owczarek, Saulius Butenas, Kinga Salapa, Tomasz Mach and Anetta Undas |
| Funding Agency and Grant Number |
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| Corresponding Author |
Danuta Owczarek, MD, PhD, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, ul. Sniadeckich 5, 31-531 Krakow, Poland. owczarek@su.krakow.pl |
| Key Words |
ADAMTS13; Inflammatory bowel disease; Thrombosis; Acquired von Willebrand syndrome; von Willebrand factor |
| Core Tip |
A tightly regulated balance between von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 (ADAMTS13) is important for haemostasis, and its dysregulation might predispose one to either thrombotic events or bleeding. We demonstrated a decrease in ADAMTS13act levels in Crohn’s disease (CD) patients, and in ADAMTS13:Ag and ADAMTS13act in ulcerative colitis (UC) patients, in whom these parameters were negatively correlated with disease activity and inflammatory markers. We report for the first time the presence of abnormalities typical of type A2 acquired von Willebrand syndrome in inflammatory bowel disease patients. These findings provide insight into the elevated risk for thromboembolic events and bleeding observed in UC and less frequently in CD. |
| Publish Date |
2017-07-12 06:45 |
| Citation |
Cibor D, Owczarek D, Butenas S, Salapa K, Mach T, Undas A. Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases. World J Gastroenterol 2017; 23(26): 4796-4805 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i26/4796.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i26.4796 |
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