Publication Name	World Journal of Gastroenterology
Manuscript ID	33218
Country	Italy

Received	2017-02-07 18:49
Peer-Review Started	2017-02-10 08:37
First Decision by Editorial Office Director
Return for Revision	2017-03-21 11:36
Revised	2017-04-03 15:41
Publication Fee Transferred
Second Decision by Editor	2017-04-27 18:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-05-04 18:31
Articles in Press	2017-05-04 18:31
Edit the Manuscript by Language Editor	2017-05-15 03:58
Typeset the Manuscript	2017-06-10 09:42
Publish the Manuscript Online	2017-06-20 12:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model
Manuscript Source	Invited Manuscript
All Author List	Chiara Dianzani, Federica Foglietta, Benedetta Ferrara, Arianna Carolina Rosa, Elisabetta Muntoni, Paolo Gasco, Carlo Della Pepa, Roberto Canaparo and Loredana Serpe
Funding Agency and Grant Number	Funding Agency Grant Number Regione Piemonte (grant “Converging Technologies”, NanoIGT) and University of Torino (grant “Ricerca Locale”, Linea A)
Corresponding Author	Loredana Serpe, MD, PhD, Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, Via Pietro Giuria 13, 10125 Torino, Italy. loredana.serpe@unito.it
Key Words	Nanoparticles; Dexamethasone; Butyrate; Inflammatory bowel disease; Drug delivery systems
Core Tip	The oral treatment with dexamethasone and butyrate co-loaded into nanoparticles was effective in achieving strong anti-inflammatory effects at doses significantly lower than those required for each single drug. This nanoformulation may open a new window on the treatment of chronic inflammatory conditions such as inflammatory bowel disease, where dose- and time-dependent side effects can limit the drug’s therapeutic usefulness. Notably, dexamethasone cholesteryl butyrate-solid lipid nanoparticles significantly relieved and repaired colon inflammation in a colitis mouse model thanks to the nanoformulation, which displayed an additive synergism among the corticosteroid, dexamethasone, and the short-chain fatty acid, butyrate.
Publish Date	2017-06-20 12:12
Citation	Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, Della Pepa C, Canaparo R, Serpe L. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol 2017; 23(23): 4200-4210
URL	http://www.wjgnet.com/1007-9327/full/v23/i23/4200.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i23.4200

Full Article (PDF)	WJG-23-4200.pdf
Full Article (Word)	WJG-23-4200.doc
Manuscript File	33218-Review.doc
Answering Reviewers	33218-Answering reviewers.pdf
Audio Core Tip	33218-Audio core tip.mp3
Biostatistics Review Certificate	33218-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33218-Conflict-of-interest statement.pdf
Copyright License Agreement	33218-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20170129052000.pdf
Institutional Animal Care and Use Committee Approval Form or Document	33218-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	33218-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	33218-Language certificate.pdf
Peer-review Report	33218-Peer-review(s).pdf
Scientific Misconduct Check	33218-Scientific misconduct check.pdf
Scientific Editor Work List	33218-Scientific editor work list.pdf