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Articles Published Processes
6/20/2017 12:12:52 PM | Browse: 1036 | Download: 2391
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Received |
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2017-02-07 18:49 |
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Peer-Review Started |
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2017-02-10 08:37 |
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To Make the First Decision |
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2017-03-16 11:51 |
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Return for Revision |
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2017-03-21 11:36 |
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Revised |
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2017-04-03 15:41 |
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Second Decision |
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2017-04-27 18:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-04 18:31 |
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Articles in Press |
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2017-05-04 18:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-05-15 03:58 |
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Typeset the Manuscript |
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2017-06-10 09:42 |
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Publish the Manuscript Online |
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2017-06-20 12:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chiara Dianzani, Federica Foglietta, Benedetta Ferrara, Arianna Carolina Rosa, Elisabetta Muntoni, Paolo Gasco, Carlo Della Pepa, Roberto Canaparo and Loredana Serpe |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Regione Piemonte (grant “Converging Technologies”, NanoIGT) and University of Torino (grant “Ricerca Locale”, Linea A) |
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| Corresponding Author |
Loredana Serpe, MD, PhD, Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, Via Pietro Giuria 13, 10125 Torino, Italy. loredana.serpe@unito.it |
| Key Words |
Nanoparticles; Dexamethasone; Butyrate; Inflammatory bowel disease; Drug delivery systems |
| Core Tip |
The oral treatment with dexamethasone and butyrate co-loaded into nanoparticles was effective in achieving strong anti-inflammatory effects at doses significantly lower than those required for each single drug. This nanoformulation may open a new window on the treatment of chronic inflammatory conditions such as inflammatory bowel disease, where dose- and time-dependent side effects can limit the drug’s therapeutic usefulness. Notably, dexamethasone cholesteryl butyrate-solid lipid nanoparticles significantly relieved and repaired colon inflammation in a colitis mouse model thanks to the nanoformulation, which displayed an additive synergism among the corticosteroid, dexamethasone, and the short-chain fatty acid, butyrate. |
| Publish Date |
2017-06-20 12:12 |
| Citation |
Dianzani C, Foglietta F, Ferrara B, Rosa AC, Muntoni E, Gasco P, Della Pepa C, Canaparo R, Serpe L. Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model. World J Gastroenterol 2017; 23(23): 4200-4210 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i23/4200.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i23.4200 |
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