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12/26/2017 1:51:01 AM | Browse: 890 | Download: 1452
Publication Name World Journal of Stem Cells
Manuscript ID 33233
Country/Territory France
Received
2017-02-09 10:05
Peer-Review Started
2017-02-13 17:25
To Make the First Decision
2017-05-10 17:20
Return for Revision
2017-05-11 18:00
Revised
2017-10-17 05:41
Second Decision
2017-10-27 06:20
Accepted by Journal Editor-in-Chief
2017-10-27 06:33
Accepted by Company Editor-in-Chief
2017-11-08 19:49
Articles in Press
2017-11-08 19:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-19 08:36
Publish the Manuscript Online
2017-12-26 01:51
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Observational Study
Article Title High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia
Manuscript Source Invited Manuscript
All Author List Adriana Plesa, Charles Dumontet, Eve Mattei, Ines Tagoug, Sandrine Hayette, Pierre Sujobert, Isabelle Tigaud, Marie Pierre Pages, Youcef Cehelgoum, Fiorenza Baracco, Helene Labussiere, Sophie Ducastelle, Etienne Paubelle, Franck Emmanuel Nicolini, Mohamed Elhamri, Lydia Campos, Claudiu Plesa, Stephan Morisset, Gilles Salles, Yves Bertrand, Mauricette Michallet and Xavier Thomas
Funding Agency and Grant Number
Corresponding Author Adriana Plesa, MD, Laboratory of Hematology, Lyon-Sud Hospital, Hospices Civils de Lyon, 165, Chemin du Grand Revoyet, Pierre - Bénite Cedex 69495, France. adriana.plesa@chu-lyon.com
Key Words CD34+CD38-/low; Immunophenotyping; Leukemic stem cells; Acute myeloid leukemia; Prognosis
Core Tip We analyzed the bone marrow samples of 200 acute myeloid leukemia (AML) patients at diagnosis by multicolour flow cytometry and investigated the prognostic value of the most immature CD34+CD38- population. We showed that a higher then > % level of CD34+CD38- blasts at diagnosis was an independent predictor of disease free survival (DFS) and overall survival in a multivariate analysis considering age, leukocytosis, the % of CD34+ blasts cells, cytogenetic and molecular risk subgroups. Despite heterogeneity and complexity of AML leukemia stem cells, we could still use CD34+CD38- quantification at diagnosis as useful complementary prognostic parameter for risk-stratification AML patients in future clinical trials.
Publish Date 2017-12-26 01:51
Citation Plesa A, Dumontet C, Mattei E, Tagoug I, Hayette S, Sujobert P, Tigaud I, Pages MP, Chelghoum Y, Baracco F, Labussierre H, Ducastelle S, Paubelle E, Nicolini FE, Elhamri M, Campos L, Plesa C, Morisset S, Salles G, Bertrand Y, Michallet M, Thomas X. High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia. World J Stem Cells 2017; 9(12): 227-234
URL http://www.wjgnet.com/1948-0210/full/v9/i12/227.htm
DOI http://dx.doi.org/10.4252/wjsc.v9.i12.227
Full Article (PDF) WJSC-9-227.pdf
Full Article (Word) WJSC-9-227.doc
Manuscript File 33233-Review.doc
Answering Reviewers 33233-Answering reviewers.pdf
Audio Core Tip 33233-Audio core tip.m4a
Biostatistics Review Certificate 33233-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33233-Conflict-of-interest statement.pdf
Copyright License Agreement 33233-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 33233-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 33233-Institutional review board statement.pdf
Supplementary Material 33233-Supplementary material.docx
Peer-review Report 33233-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33233-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33233-Scientific misconduct check.pdf
Scientific Editor Work List 33233-Scientific editor work list.pdf