Publication Name	World Journal of Orthopedics
Manuscript ID	33239
Country	United States

Received	2017-02-08 14:19
Peer-Review Started	2017-02-13 17:19
To Make the First Decision	2017-05-10 17:20
Return for Revision	2017-05-11 18:04
Revised	2017-05-27 00:44
Second Decision	2017-08-10 03:38
Accepted by Journal Editor-in-Chief	2017-08-10 07:49
Accepted by Executive Editor-in-Chief	2017-08-16 02:33
Articles in Press	2017-08-16 02:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-21 03:02
Publish the Manuscript Online	2017-12-18 03:37

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Systematic review of bone marrow stimulation for osteochondral lesion of talus - evaluation for level and quality of clinical studies
Manuscript Source	Invited Manuscript
All Author List	Youichi Yasui, Laura Ramponi, Dexter Show, Eoghan T Hurley, Wataru Miyamoto, Yoshiharu Shimozono and John G Kennedy
Funding Agency and Grant Number
Corresponding Author	Youichi Yasui, MD, Department of Orthopaedic Surgery, 2nd Teikyo University School of Medicine, 1-1 Kaga, 2-Chome, Itabashi-Ku, Tokyo 173-8606, Japan. youichi@med.teikyo-u.ac.jp
Key Words	Osteochondral lesion of talus; Arthroscopy; Bone marrow stimulation; Systematic review
Core Tip	Bone marrow stimulation (BMS) is a reparative procedure for osteochondral lesions of the talus, promising approximately 85% success rates in the short- and mid-term. To date, the prognostic factors for BMS are lesion size and containment of the lesion. No other factors have been shown to be universal predictors. However, the level of evidence and methodological quality of evidence for clinical studies accompanying both the lesion sizes and containment are low. Overall, 95.5% of the studies included in the analysis are level Ⅳ or level Ⅲ. No level Ⅰ study was identified. The methodological qualities of the included studies were not strong. In particular, the scores of “primarily evaluates outcome criteria and recruitment rates” were low.
Publish Date	2017-12-18 03:37
Citation	Yasui Y, Ramponi L, Seow D, Hurley ET, Miyamoto W, Shimozono Y, Kennedy JG. Systematic review of bone marrow stimulation for osteochondral lesion of talus - evaluation for level and quality of clinical studies. World J Orthop 2017; 8(12): 956-963
URL	http://www.wjgnet.com/2218-5836/full/v8/i12/956.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i12.956

Full Article (PDF)	WJO-8-956.pdf
Full Article (Word)	WJO-8-956.doc
Manuscript File	33239-Review.docx
Answering Reviewers	33239-Answering reviewers.pdf
Audio Core Tip	33239-Audio core tip.m4a
Biostatistics Review Certificate	33239-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33239-Conflict-of-interest statement.pdf
Copyright License Agreement	33239-Copyright assignment.pdf
Peer-review Report	33239-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33239-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33239-Scientific misconduct check.pdf
Scientific Editor Work List	33239-Scientific editor work list.pdf