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11/13/2017 1:14:28 AM | Browse: 1000 | Download: 1599
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 33241
Country/Territory United States
Received
2017-02-08 14:16
Peer-Review Started
2017-02-13 09:51
To Make the First Decision
2017-07-10 00:36
Return for Revision
2017-07-10 08:26
Revised
2017-07-25 02:00
Second Decision
2017-08-10 03:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-04 23:43
Articles in Press
2017-09-04 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-11-02 07:47
Publish the Manuscript Online
2017-11-13 01:14
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion
Manuscript Source Invited Manuscript
All Author List Benjamin S Maciejewski, Tara B Manion and Claire M Steppan
Funding Agency and Grant Number
Funding Agency Grant Number
Pfizer Inc.
Corresponding Author Claire M Steppan, PhD, Pfizer Inc., Eastern Point Road, Groton, CT 06340, United States. claire.m.steppan@pfizer.com
Key Words Glucagon-like peptide-1; Peptide tyrosine-tyrosine; Glucose independent insulinotropic peptide; Acyl-CoA:diacylglycerol acyltransferase-1; Incretin
Core Tip Pharmacological Inhibition of diacylglycerol acyltransferase-1 (DGAT1) and insights into postprandial gut peptide secretion” describes studies that evaluate the effects of loss of DGAT1 function either pharmacologically or genetically on the incretin response. We demonstrate a synergistic effect on the incretin response with the combination of a DGAT1 inhibitor and sitagliptin, a dipeptidyl peptidase-Ⅳ inhibitor. Additional studies performed address the molecular mechanism by with pharmacological inhibition of DGAT1 results in increased gut peptide secretion. These data provide insight into the role of DGAT1 in the intestinal hormone release and its potential as a drug target for the treatment of type 2 diabetes.
Publish Date 2017-11-13 01:14
Citation Maciejewski BS, Manion TB, Steppan CM. Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion. World J Gastrointest Pathophysiol 2017; 8(4): 161-175
URL http://www.wjgnet.com/2150-5330/full/v8/i4/161.htm
DOI http://dx.doi.org/10.4291/wjgp.v8.i4.161
Full Article (PDF) WJGP-8-161.pdf
Full Article (Word) WJGP-8-161.doc
Manuscript File 33241-Review.docx
Answering Reviewers 33241-Answering reviewers.pdf
Audio Core Tip 33241-Audio core tip.m4a
Biostatistics Review Certificate Biostatistics_Statement_20170129114427.docx
Conflict-of-Interest Disclosure Form 33241-Conflict-of-interest statement.pdf
Copyright License Agreement 33241-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33241-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 33241-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33241-Institutional review board statement.pdf
Peer-review Report 33241-Peer-review(s).pdf
Scientific Misconduct Check 33241-Scientific misconduct check.pdf
Scientific Editor Work List 33241-Scientific editor work list.pdf