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Articles Published Processes
11/13/2017 1:14:28 AM | Browse: 1130 | Download: 1991
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Received |
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2017-02-08 14:16 |
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Peer-Review Started |
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2017-02-13 09:51 |
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To Make the First Decision |
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2017-07-10 00:36 |
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Return for Revision |
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2017-07-10 08:26 |
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Revised |
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2017-07-25 02:00 |
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Second Decision |
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2017-08-10 03:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-09-04 23:43 |
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Articles in Press |
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2017-09-04 23:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-02 07:47 |
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Publish the Manuscript Online |
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2017-11-13 01:14 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Benjamin S Maciejewski, Tara B Manion and Claire M Steppan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Pfizer Inc. |
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| Corresponding Author |
Claire M Steppan, PhD, Pfizer Inc., Eastern Point Road, Groton, CT 06340, United States. claire.m.steppan@pfizer.com |
| Key Words |
Glucagon-like peptide-1; Peptide tyrosine-tyrosine; Glucose independent insulinotropic peptide; Acyl-CoA:diacylglycerol acyltransferase-1; Incretin |
| Core Tip |
Pharmacological Inhibition of diacylglycerol acyltransferase-1 (DGAT1) and insights into postprandial gut peptide secretion” describes studies that evaluate the effects of loss of DGAT1 function either pharmacologically or genetically on the incretin response. We demonstrate a synergistic effect on the incretin response with the combination of a DGAT1 inhibitor and sitagliptin, a dipeptidyl peptidase-Ⅳ inhibitor. Additional studies performed address the molecular mechanism by with pharmacological inhibition of DGAT1 results in increased gut peptide secretion. These data provide insight into the role of DGAT1 in the intestinal hormone release and its potential as a drug target for the treatment of type 2 diabetes. |
| Publish Date |
2017-11-13 01:14 |
| Citation |
Maciejewski BS, Manion TB, Steppan CM. Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion. World J Gastrointest Pathophysiol 2017; 8(4): 161-175 |
| URL |
http://www.wjgnet.com/2150-5330/full/v8/i4/161.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v8.i4.161 |
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