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9/13/2017 7:36:12 AM | Browse: 342 | Download: 326
Publication Name World Journal of Diabetes
Manuscript ID 33256
Country/Territory Italy
Received
2017-02-08 11:50
Peer-Review Started
2017-02-12 20:01
To Make the First Decision
2017-03-27 11:21
Return for Revision
2017-03-28 15:08
Revised
2017-04-04 19:15
Second Decision
2017-04-14 11:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-05 16:27
Articles in Press
2017-05-05 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-08 07:20
Publish the Manuscript Online
2017-09-13 07:36
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance
Manuscript Source Invited Manuscript
All Author List Biagio Arcidiacono, Eusebio Chiefari, Anna Elisa Laria, Sebastiano Messineo, Francesco Luciano Bilotta, Domenico Britti, Daniela Patrizia Foti, Anna Foryst-Ludwig, Ulrich Kintscher and Antonio Brunetti
Funding Agency and Grant Number
Corresponding author Antonio Brunetti, MD, PhD, Professor of Endocrinology, Department of Health Sciences, University “Magna Græcia” of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy. brunetti@unicz.it
Keywords Metalloproteinase-11; Insulin resistance; Type 2 diabetes; Fibrosis; Hypoxia; Tumor necrosis factor-α; Inflammation
Core Tip 3T3-L1 mature adipocytes are widely used as a cellular model of obesity. We treated 3T3-L1 adipocytes with tumor necrosis factor-α and/or hypoxia for 24 h to induce insulin resistance. Matrix metalloproteinase-11 (MMP-11) expression levels were upregulated in insulin resistant adipocytes, as compared to untreated control cells. This observation was confirmed in vivo, in white adipose tissue from insulin-resistant obese mice. Therefore, our results suggest that MMP-11 could play a role in the dysfunction of adipose tissue, which leads to insulin resistance and type 2 diabetes. Further work is necessary to understand better the functional role of MMP-11 in this context.
Publish Date 2017-09-13 07:36
Citation Arcidiacono B, Chiefari E, Laria AE, Messineo S, Bilotta FL, Britti D, Foti DP, Foryst-Ludwig A, Kintscher U, Brunetti A. Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance. World J Diabetes 2017; 8(9): 422-428
Url http://www.wjgnet.com/1948-9358/full/v8/i9/422.htm
DOI http://dx.doi.org/10.4239/wjd.v8.i9.422
Full Article (PDF) WJD-8-422.pdf
Full Article (Word) WJD-8-422.doc
Manuscript File 33256-Review.docx
Answering Reviewers 33256-Answering reviewers.pdf
Audio Core Tip 33256-Audio core tip.wav
Biostatistics Review Certificate 33256-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33256-Conflict-of-interest statement.pdf
Copyright License Agreement 33256-Copyright assignment.pdf
Data Sharing Statement 33256-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33256-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33256-Institutional review board statement.pdf
Scientific Research Process 33256-Scientific research process.pdf
Peer-review Report 33256-Peer-review(s).pdf
Scientific Misconduct Check 33256-Scientific misconduct check.pdf
Scientific Editor Work List 33256-Scientific editor work list.pdf