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Articles Published Processes
9/13/2017 7:36:12 AM | Browse: 1187 | Download: 2328
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Received |
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2017-02-08 11:50 |
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Peer-Review Started |
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2017-02-12 20:01 |
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To Make the First Decision |
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2017-03-27 11:21 |
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Return for Revision |
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2017-03-28 15:08 |
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Revised |
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2017-04-04 19:15 |
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Second Decision |
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2017-04-14 11:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-05 16:27 |
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Articles in Press |
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2017-05-05 16:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-08 07:20 |
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Publish the Manuscript Online |
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2017-09-13 07:36 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Biagio Arcidiacono, Eusebio Chiefari, Anna Elisa Laria, Sebastiano Messineo, Francesco Luciano Bilotta, Domenico Britti, Daniela Patrizia Foti, Anna Foryst-Ludwig, Ulrich Kintscher and Antonio Brunetti |
| Funding Agency and Grant Number |
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| Corresponding Author |
Antonio Brunetti, MD, PhD, Professor of Endocrinology, Department of Health Sciences, University “Magna Græcia” of Catanzaro, Viale Europa (Località Germaneto), 88100 Catanzaro, Italy. brunetti@unicz.it |
| Key Words |
Metalloproteinase-11; Insulin resistance; Type 2 diabetes; Fibrosis; Hypoxia; Tumor necrosis factor-α; Inflammation |
| Core Tip |
3T3-L1 mature adipocytes are widely used as a cellular model of obesity. We treated 3T3-L1 adipocytes with tumor necrosis factor-α and/or hypoxia for 24 h to induce insulin resistance. Matrix metalloproteinase-11 (MMP-11) expression levels were upregulated in insulin resistant adipocytes, as compared to untreated control cells. This observation was confirmed in vivo, in white adipose tissue from insulin-resistant obese mice. Therefore, our results suggest that MMP-11 could play a role in the dysfunction of adipose tissue, which leads to insulin resistance and type 2 diabetes. Further work is necessary to understand better the functional role of MMP-11 in this context. |
| Publish Date |
2017-09-13 07:36 |
| Citation |
Arcidiacono B, Chiefari E, Laria AE, Messineo S, Bilotta FL, Britti D, Foti DP, Foryst-Ludwig A, Kintscher U, Brunetti A. Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance. World J Diabetes 2017; 8(9): 422-428 |
| URL |
http://www.wjgnet.com/1948-9358/full/v8/i9/422.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v8.i9.422 |
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