Publication Name	World Journal of Diabetes
Manuscript ID	33261
Country	Greece

Received	2017-02-08 11:47
Peer-Review Started	2017-02-12 20:37
To Make the First Decision	2017-03-27 11:21
Return for Revision	2017-03-28 15:11
Revised	2017-04-10 15:48
Second Decision	2017-04-24 17:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-05 16:28
Articles in Press	2017-05-05 16:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-05-19 08:10
Typeset the Manuscript	2017-06-04 07:30
Publish the Manuscript Online	2017-06-15 02:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Effects of glucose-lowering agents on ischemic stroke
Manuscript Source	Invited Manuscript
All Author List	Konstantinos Avgerinos and Konstantinos Tziomalos
Funding Agency and Grant Number
Corresponding Author	Konstantinos Tziomalos, MD, PhD, Assistant Professor of Internal Medicine, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 54636 Thessaloniki, Greece. ktziomal@auth.gr
Key Words	Antidiabetic treatment; Ischemic stroke; Cardiovascular events; Glucose regulation; Neuro­protection
Core Tip	Diabetes mellitus is a major risk factor for ischemic stroke. However, strict glycemic control does not appear to reduce the risk of ischemic stroke. On the other hand, glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors reduce the risk of cardiovascular events. These benefits are independent of glucose lowering and might be due to favorable effects on weight and blood pressure. Pioglitazone also reduced the risk of recurrent stroke but the unfavorable safety profile limits its use. Finally, sulfonylureas and dipeptidyl-peptidase-4 inhibitors have neutral effects on cardiovascular morbidity and might be less attractive options.
Publish Date	2017-06-15 02:07
Citation	Avgerinos K, Tziomalos K. Effects of glucose-lowering agents on ischemic stroke. World J Diabetes 2017; 8(6): 270-277
URL	http://www.wjgnet.com/1948-9358/full/v8/i6/270.htm
DOI	http://dx.doi.org/10.4239/wjd.v8.i6.270

Full Article (PDF)	WJD-8-270.pdf
Full Article (Word)	WJD-8-270.doc
Manuscript File	33261-Review.docx
Answering Reviewers	33261-Answering reviewers.pdf
Audio Core Tip	33261-Audio core tip.wma
Conflict-of-Interest Disclosure Form	33261-Conflict-of-interest statement.pdf
Copyright License Agreement	33261-Copyright assignment.pdf
Peer-review Report	33261-Peer-review(s).pdf
Scientific Misconduct Check	33261-Scientific misconduct check.pdf
Scientific Editor Work List	33261-Scientific editor work list.pdf