Publication Name	World Journal of Orthopedics
Manuscript ID	33271
Country	Thailand

Received	2017-02-08 11:23
Peer-Review Started	2017-02-12 21:39
To Make the First Decision	2017-03-27 11:21
Return for Revision	2017-03-28 15:24
Revised	2017-03-31 20:32
Second Decision	2017-05-02 11:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-05-15 04:15
Articles in Press	2017-05-15 04:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-07 03:23
Publish the Manuscript Online	2017-09-13 00:54

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Prospective Study
Article Title	Association of adiponectin gene polymorphisms with knee osteoarthritis
Manuscript Source	Invited Manuscript
All Author List	Dong Zhan, Suthimon Thumtecho, Aree Tanavalee, Pongsak Yuktanandana, Wilai Anomasiri and Sittisak Honsawek
Funding Agency and Grant Number
Corresponding Author	Sittisak Honsawek, Professor, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Rd, Patumwan, Bangkok 10330, Thailand. sittisak.h@chula.ac.th
Key Words	Adiponectin; ADIPOQ; Polymorphism; Knee osteoarthritis; Plasma
Core Tip	Plasma adiponectin levels were significantly lower in knee osteoarthritis (OA) than controls. No significant associations were observed in the genotype distributions and allele frequencies of ADIPOQ +45T/G and +276G/T polymorphisms between knee OA subjects and controls. There was a significant association between genotype distribution of +276G/T polymorphism and OA severity. In addition, plasma adiponectin in OA subjects was seemingly lower than that in control subjects in GG genotype of +45T/G and +276G/T polymorphisms. Polymorphisms +45T/G and +276G/T of the ADIPOQ gene might not be responsible for the susceptibility to knee OA in the Thai population.
Publish Date	2017-09-13 00:54
Citation	Zhan D, Thumtecho S, Tanavalee A, Yuktanandana P, Anomasiri W, Honsawek S. Association of adiponectin gene polymorphisms with knee osteoarthritis. World J Orthop 2017; 8(9): 719-725
URL	http://www.wjgnet.com/2218-5836/full/v8/i9/719.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i9.719

Full Article (PDF)	WJO-8-719.pdf
Full Article (Word)	WJO-8-719.doc
Manuscript File	33271-Review.doc
Answering Reviewers	33271-Answering reviewers.pdf
Audio Core Tip	33271-Audio core tip.mp3
Biostatistics Review Certificate	33271-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	33271-Conflict-of-interest statement.pdf
Copyright License Agreement	33271-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	33271-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	33271-Institutional review board statement.pdf
Peer-review Report	33271-Peer-review(s).pdf
Scientific Misconduct Check	33271-Scientific misconduct check.pdf
Scientific Editor Work List	33271-Scientific editor work list.pdf