Publication Name	World Journal of Clinical Oncology
Manuscript ID	33274
Country	Canada

Received	2017-02-08 11:09
Peer-Review Started	2017-02-12 21:53
To Make the First Decision	2017-03-27 11:21
Return for Revision	2017-03-28 15:30
Revised	2017-04-12 11:39
Second Decision	2017-05-11 13:48
Accepted by Journal Editor-in-Chief	2017-05-11 23:16
Accepted by Company Editor-in-Chief	2017-05-31 02:46
Articles in Press	2017-05-31 02:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-03 03:48
Publish the Manuscript Online	2017-08-08 01:51

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Case Report
Article Title	Long-term stabilization of metastatic melanoma with sodium dichloroacetate
Manuscript Source	Invited Manuscript
All Author List	Akbar Khan, Doug Andrews, Jill Shainhouse and Anneke C Blackburn
Funding Agency and Grant Number
Corresponding Author	Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc, 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan@medicorcancer.com
Key Words	Dichloroacetate; Cancer; BRAF; Melanoma; Cytostatic
Core Tip	Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007. It has been shown that DCA therapy can result in a classic response which is measured by reduction or disappearance of tumours on imaging. However, DCA can also halt cancer cell growth without causing apoptosis (cytostatic effect). This can result in long-term stabilization of metastatic cancer. We present a case of oral DCA therapy resulting in reduction and stabilization of metastatic melanoma in a 32-year-old male for over 4 years, with only minor side effects.
Publish Date	2017-08-08 01:51
Citation	Khan A, Andrews D, Shainhouse J, Blackburn AC. Long-term stabilization of metastatic melanoma with sodium dichloroacetate. World J Clin Oncol 2017; 8(4): 371-377
URL	http://www.wjgnet.com/2218-4333/full/v8/i4/371.htm
DOI	http://dx.doi.org/10.5306/wjco.v8.i4.371

Full Article (PDF)	WJCO-8-371.pdf
Full Article (Word)	WJCO-8-371.doc
Manuscript File	33274-Review.docx
Answering Reviewers	33274-Answering reviewers.pdf
Audio Core Tip	33274-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33274-Conflict-of-interest statement.pdf
Copyright License Agreement	33274-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	33274-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	33274-Institutional review board statement.pdf
Peer-review Report	33274-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33274-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33274-Scientific misconduct check.pdf
Scientific Editor Work List	33274-Scientific editor work list.pdf