Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	3329
Country	United States

Received	2013-04-23 09:38
Peer-Review Started	2013-04-23 19:35
To Make the First Decision	2013-07-19 08:53
Return for Revision	2013-07-20 22:45
Revised
Second Decision	2014-01-16 14:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-16 14:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 20:53
Publish the Manuscript Online	2014-03-20 18:58

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation
Manuscript Source	Invited Manuscript
All Author List	H Caitlin A Schonewolf, Monal Mehta, Devora Schiff, Hao Wu, Bruce G Haffty, Vassiliki Karantza and Salma K Jabbour
Funding Agency and Grant Number
Corresponding Author	Salma K Jabbour, MD, Departments of Radiation Oncology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, United States. jabbousk@umdnj.edu
Key Words	Autophagy; Chloroquine; Radiosensitization; Colorectal cancer
Core Tip	Autophagy is implicated as a mechanism of resistance to cancer treatment. We hypothesized that chloroquine, a lysosomotropic autophagy inhibitor, would sensitize colorectal cancer (CRC) cell lines to both radiation therapy (RT) alone and concurrent chemoradiation. Our results showed that chloroquine decreased clonogenic survival of CRC cells when given in combination with RT or concurrent 5-fluorouracil and RT. Radiosensitization by chloroquine represents a novel therapeutic approach to enhance treatment efficacy in rectal cancer.
Publish Date	2014-03-20 18:58
Citation	Schonewolf CA, Mehta M, Schiff D, Wu H, Haffty BG, Karantza V, Jabbour SK. Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation. World J Gastrointest Oncol 2014; 6(3): 74-82
URL	http://www.wjgnet.com/1948-5204/full/v6/i3/74.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i3.74

Full Article (PDF)	wjgo-6-74.pdf
Full Article (Word)	wjgo-6-74.doc
Manuscript File	3329-Review.docx
Answering Reviewers	3329-Answering reviewers.pdf
Copyright License Agreement	3329-Copyright assignment.pdf
Peer-review Report	3329-Peer review(s).pdf
Scientific Editor Work List	3329-Scientific editor work list.doc