Publication Name	World Journal of Cardiology
Manuscript ID	3330
Country	Italy

Received	2013-04-23 09:47
Peer-Review Started	2013-04-23 19:43
To Make the First Decision	2013-05-14 18:54
Return for Revision	2013-05-18 15:57
Revised	2013-06-05 05:11
Second Decision	2013-06-18 14:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-19 01:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-11 18:58
Publish the Manuscript Online	2013-08-02 14:08

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Case Report
Article Title	Berberine behind the thriller of marked symptomatic bradycardia
Manuscript Source	Invited Manuscript
All Author List	Margherita Cannillo, Simone Frea, Cristina Fornengo, Elisabetta Toso, Giancarlo Mercurio, Stefania Battista and Fiorenzo Gaita
Funding Agency and Grant Number
Corresponding Author	Margherita Cannillo, MD, Division of Cardiology, Cardiovascular Department, AOU S. Giovanni Battista di Torino and University of Torino, Corso Bramante 88, 10100 Turino, Italy. margheritacannillo@gmail.com.
Key Words	Berberine; Bradyarrhythmia; Side effect; Hypervagotonia; Hypercholesterolaemia; Electrocardiogram
Core Tip	Berberine is widely used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia. We report a case of marked symptomatic sinus bradycardia with competitive junctional rhythm caused by berberine, showing that berberine, due to its antiarrhythmic properties, can cause the onset of bradyarrhythmia. In this case report, we focus on the possible side effects of so-called natural medicine based on holistic, home, and herbal remedies, which is considered to be safe only because the treatment is natural. However, under certain conditions, natural medicine can lead to potential health risks in patients.
Publish Date	2013-08-02 14:08
Citation	Cannillo M, Frea S, Fornengo C, Toso E, Mercurio G, Battista S, Gaita F. Berberine behind the thriller of marked symptomatic bradycardia. World J Cardiol 2013; 5(7): 261-264
URL	http://www.wjgnet.com/1949-8462/full/v5/i7/261.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i7.261

Full Article (PDF)	WJC-5-261.pdf
Manuscript File	3330-Review.doc
Answering Reviewers	3330-Answering reviewers.pdf
Copyright License Agreement	3330-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3330-Language certificate.pdf
Peer-review Report	3330-Peer review(s).pdf
Scientific Editor Work List	3330-Scientific editor work list.doc