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7/7/2017 11:41:16 AM | Browse: 1181 | Download: 1470
Publication Name World Journal of Gastroenterology
Manuscript ID 33337
Country/Territory Brazil
Received
2017-02-07 10:00
Peer-Review Started
2017-02-09 14:42
To Make the First Decision
2017-02-23 09:56
Return for Revision
2017-02-27 16:50
Revised
2017-03-03 08:26
Second Decision
2017-06-09 05:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-12 08:34
Articles in Press
2017-06-12 08:34
Publication Fee Transferred
2017-06-12 19:49
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-27 10:16
Publish the Manuscript Online
2017-07-07 11:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Glutamine prevents oxidative stress in a model of portal hypertension
Manuscript Source Unsolicited Manuscript
All Author List Gilmara Pandolfo Zabot, Gustavo Franco Carvalhal, Norma Possa Marroni, Francielli Licks, Renata Minuzzo Hartmann, Vinícius Duval da Silva and Henrique Sarubbi Fillmann
Funding Agency and Grant Number
Corresponding Author Gilmara Pandolfo Zabot, Ms, Sci, Department of Surgery, School of Medicine, Pontifical Catholic University of Rio Grande do Sul; Duque de Caxias Street, 1012/19, Marechal Rondon, Canoas, RS 90610-000, Brazil. gilmarapandolfo@terra.com.br
Key Words Portal hypertension; Endothelial nitric oxide synthase; Glutamine; Glutathione peroxidase; Inducible nitric oxide synthase; Lipid peroxidation
Core Tip Portal hypertension (PH) is characterized by an increased portal pressure gradient. The progressive increase in portal pressure leads to the formation of portosystemic shunts and intestinal hypoxia. Many enzymes have been implicated in this process, among them endothelial nitric oxide synthase and inducible nitric oxide synthase. Some substances, such as glutamine, have been studied as protective agents against oxidative stress. In an experimental model of PH induced by partial portal vein ligation, we have found that glutamine reduced lipid peroxidation and preserved intestinal glutathione peroxidase activity, suggesting a protective role of this amino acid in the setting of PH.
Publish Date 2017-07-07 11:41
Citation Zabot GP, Carvalhal GF, Marroni NP, Licks F, Hartmann RM, da Silva VD, Fillmann HS. Glutamine prevents oxidative stress in a model of portal hypertension. World J Gastroenterol 2017; 23(25): 4529-4537
URL http://www.wjgnet.com/1007-9327/full/v23/i25/4529.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i25.4529
Full Article (PDF) WJG-23-4529.pdf
Full Article (Word) WJG-23-4529.doc
Manuscript File 33337-Review.doc
Answering Reviewers 33337-Answering reviewers.pdf
Audio Core Tip 33337-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20170202221442.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20170202223512.png
Conflict-of-Interest Disclosure Form 33337-Conflict-of-interest statement.pdf
Copyright License Agreement 33337-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) Grant_Application_Form_20170202222434.png
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170202223312.doc
Institutional Animal Care and Use Committee Approval Form or Document 33337-Institutional animal care and use commmmittee statement.pdf
Institutional Review Board Approval Form or Document 33337-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33337-Language certificate.pdf
Peer-review Report 33337-Peer-review(s).pdf
Scientific Misconduct Check 33337-Scientific misconduct check.pdf
Scientific Editor Work List 33337-Scientific editor work list.pdf