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Articles Published Processes
7/7/2017 11:41:16 AM | Browse: 1326 | Download: 1992
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Received |
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2017-02-07 10:00 |
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Peer-Review Started |
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2017-02-09 14:42 |
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To Make the First Decision |
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2017-02-23 09:56 |
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Return for Revision |
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2017-02-27 16:50 |
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Revised |
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2017-03-03 08:26 |
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Second Decision |
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2017-06-09 05:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-12 08:34 |
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Articles in Press |
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2017-06-12 08:34 |
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Publication Fee Transferred |
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2017-06-12 19:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-06-27 10:16 |
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Publish the Manuscript Online |
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2017-07-07 11:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Glutamine prevents oxidative stress in a model of portal hypertension
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gilmara Pandolfo Zabot, Gustavo Franco Carvalhal, Norma Possa Marroni, Francielli Licks, Renata Minuzzo Hartmann, Vinícius Duval da Silva and Henrique Sarubbi Fillmann |
| Funding Agency and Grant Number |
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| Corresponding Author |
Gilmara Pandolfo Zabot, Ms, Sci, Department of Surgery, School of Medicine, Pontifical Catholic University of Rio Grande do Sul; Duque de Caxias Street, 1012/19, Marechal Rondon, Canoas, RS 90610-000, Brazil. gilmarapandolfo@terra.com.br |
| Key Words |
Portal hypertension; Endothelial nitric oxide synthase; Glutamine; Glutathione peroxidase; Inducible nitric oxide synthase; Lipid peroxidation |
| Core Tip |
Portal hypertension (PH) is characterized by an increased portal pressure gradient. The progressive increase in portal pressure leads to the formation of portosystemic shunts and intestinal hypoxia. Many enzymes have been implicated in this process, among them endothelial nitric oxide synthase and inducible nitric oxide synthase. Some substances, such as glutamine, have been studied as protective agents against oxidative stress. In an experimental model of PH induced by partial portal vein ligation, we have found that glutamine reduced lipid peroxidation and preserved intestinal glutathione peroxidase activity, suggesting a protective role of this amino acid in the setting of PH. |
| Publish Date |
2017-07-07 11:41 |
| Citation |
Zabot GP, Carvalhal GF, Marroni NP, Licks F, Hartmann RM, da Silva VD, Fillmann HS. Glutamine prevents oxidative stress in a model of portal hypertension. World J Gastroenterol 2017; 23(25): 4529-4537 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i25/4529.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i25.4529 |
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