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Articles Published Processes
9/7/2017 8:51:55 AM | Browse: 1025 | Download: 1963
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Received |
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2017-02-07 09:10 |
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Peer-Review Started |
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2017-02-08 14:44 |
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To Make the First Decision |
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2017-05-12 08:46 |
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Return for Revision |
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2017-05-16 03:13 |
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Revised |
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2017-06-10 01:44 |
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Second Decision |
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2017-06-27 01:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-04 05:59 |
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Articles in Press |
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2017-07-04 05:59 |
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Publication Fee Transferred |
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2017-07-08 17:24 |
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Edit the Manuscript by Language Editor |
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2017-08-04 21:02 |
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Typeset the Manuscript |
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2017-08-25 06:59 |
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Publish the Manuscript Online |
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2017-09-07 08:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Chen, Ping An, Xiao-Jing Quan, Jun Zhang, Zhong-Yin Zou and He-Sheng Luo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81302131 |
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| Corresponding Author |
He-Sheng Luo, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, Hubei Province, China. xhnk@163.com |
| Key Words |
Ca2+/calmodulin-dependent protein kinase II; Colon cancer; Proliferation; Migration |
| Core Tip |
In the present study, we demonstrated that calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) was over-expressed in human colon cancers and was associated with cancer differentiation. We investigated the role of CaMKII in human colon cancer proliferation and migration. The results revealed that in the human colon cancer cell line HCT116, the CaMKⅡ-specific inhibitor KN93, but not its inactive analogue KN92, decreased cancer cell proliferation. KN93 also significantly prohibited colon cancer cell migration and invasion. Additionally, we found that ERK1/2 and p38 were the targets of CaMKⅡ regulation. These findings highlight CaMKⅡ as a potential critical mediator in human colon tumor development and metastasis. |
| Publish Date |
2017-09-07 08:51 |
| Citation |
Chen W, An P, Quan XJ, Zhang J, Zhou ZY, Zou LP, Luo HS. Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways. World J Gastroenterol 2017; 23(33): 6111-6118 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i33/6111.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i33.6111 |
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