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Articles Published Processes
8/7/2017 9:17:02 AM | Browse: 1033 | Download: 1993
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Received |
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2017-02-08 10:04 |
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Peer-Review Started |
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2017-02-08 20:01 |
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To Make the First Decision |
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2017-03-30 13:25 |
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Return for Revision |
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2017-03-31 15:55 |
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Revised |
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2017-05-22 07:09 |
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Second Decision |
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2017-05-27 01:43 |
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Accepted by Journal Editor-in-Chief |
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2017-05-27 12:26 |
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Accepted by Executive Editor-in-Chief |
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2017-06-01 07:00 |
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Articles in Press |
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2017-06-01 07:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-25 11:42 |
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Publish the Manuscript Online |
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2017-08-07 09:17 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Swati Valmiki, Vineet Ahuja and Jaishree Paul |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Biotechnology, Ministry of Science and Technology, New Delhi, Government of India vide BT/PR8348/MED/30/1023/2013 (to JP) |
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| Partial funding was also obtained from PURSE grant from the Department of Science and Technology, New Delhi India vide 6(54) SLS/JP/DST PURSE/2015-2016 |
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| Corresponding Author |
Dr. Jaishree Paul, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India. jaishree@mail.jnu.ac.in |
| Key Words |
Ulcerative colitis; Colon mucosa; MicroRNA; Microarray; qRT-PCR; In silico analysis |
| Core Tip |
In order to get an insight into the pathogenesis of ulcerative colitis (UC), we explored spatial expression of microRNA in the inflamed and non-inflamed region of mucosal tissue of patients. Profiling of differentially expressed miRNA was generated by microarray from three paired samples. Few significantly dysregulated microRNA were validated using qRT-PCR. The present study reports disease specific alteration in the expression of miR-125b, miR-155, miR-223 and miR-138 in UC patients and also analyzed their biological significance using in silico tools. MiR-223 exhibited elevated expression independent of disease activity therefore, could be a potential candidate as biomarker for UC. |
| Publish Date |
2017-08-07 09:17 |
| Citation |
Valmiki S, Ahuja V, Paul J. MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients. World J Gastroenterol 2017; 23(29): 5324-5332 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i29/5324.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i29.5324 |
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